中文版 | English

个人主页

关键词云

成果统计

合作作者[TOP 5]

  • 吴屹然

    合作成果数：49

  • Raymond C. Stevens

    合作成果数：24

  • 刘志杰

    合作成果数：21

  • 周庆同

    合作成果数：19

  • 徐菲

    合作成果数：18

访问统计


  总访问量
 5625
  访问来源
    内部： 35
    外部： 5590
    国内： 5160
    国外： 465

  年访问量
 262
  访问来源
    内部： 0
    外部： 262
    国内： 244
    国外： 18

  月访问量
 102
  访问来源
    内部： 0
    外部： 102
    国内： 97
    国外： 5

访问量

访问量

1. A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine .. [21652]
2. Crystal Structure of the Human Cannabinoid Receptor CB2 [5588]
3. A structurally guided dissection-then-evolution strategy for ligan.. [3203]
4. Genome-wide CRISPR screen identifies FAM49B as a key regulator of .. [3102]
5. High-throughput identification of G protein-coupled receptor modul.. [2716]
6. Crystal Structure of the Human Cannabinoid Receptor CB1 [2513]
7. Structural Basis of the Diversity of Adrenergic Receptors [2426]
8. Crystal structure of a constitutive active mutant of adenosine A(2.. [2248]
9. G protein-coupled receptors: structure- and function-based drug di.. [1987]
10. Crystal structure of a multi-domain human smoothened receptor in c.. [1623]
11. Ligands of Adrenergic Receptors: A Structural Point of View [1587]
12. Molecular Mechanism for Ligand Recognition and Subtype Selectivity.. [1581]
13. Cryo-EM structures of orphan GPR21 signaling complexes [1561]
14. Crystal structures of agonist-bound human cannabinoid receptor CB1 [1417]
15. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Pol.. [1376]
16. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing .. [1342]
17. Structural insights into the committed step of bacterial phospholi.. [1268]
18. The unconventional activation of the muscarinic acetylcholine rece.. [1256]
19. Salvianolic acids from antithrombotic Traditional Chinese Medicine.. [1251]
20. Structural basis for strychnine activation of human bitter taste r.. [1220]
21. Salvianolic acids from antithrombotic Traditional Chinese Medicine.. [1197]
22. The activation mechanism and antibody binding mode for orphan GPR2.. [1175]
23. Identification of natural products as novel ligands for the human .. [1160]
24. Human GLP-1 receptor transmembrane domain structure in complex wit.. [1159]
25. Disulfide-Containing Detergents (DCDs) for the Structural Biology .. [1113]
26. Discovery of Novel Allosteric Modulators Targeting an Extra-Helica.. [1112]
27. Molecular Mechanism of Acetate Transport through the Acetate Chann.. [1111]
28. Crystal structure of the Frizzled 4 receptor in a ligand-free stat.. [1110]
29. Structural basis of CXC chemokine receptor 2 activation and signal.. [1072]
30. Determination of an underneath binding in the transmembrane domain.. [1055]
31. Colocalization Strategy Unveils an Underside Binding Site in the T.. [1054]
32. Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Si.. [1021]
33. MD Simulations Revealing Special Activation Mechanism of Cannabino.. [967]
34. Succinate-acetate permease from Citrobacter koseri is an anion cha.. [867]
35. Filamentation of asparagine synthetase in Saccharomyces cerevisiae [864]
36. Activation and Signaling Mechanism Revealed by Cannabinoid Recepto.. [837]
37. The structural study of mutation-induced inactivation of human mus.. [836]
38. The structure-based traceless specific fluorescence labeling of th.. [830]
39. Rational Remodeling of Atypical Scaffolds for the Design of Photos.. [828]
40. Structural Basis for Apelin Control of the Human Apelin Receptor [827]
41. Elucidation of Distinct Modular Assemblies of Smoothened Receptor .. [825]
42. A unique hormonal recognition feature of the human glucagon-like p.. [821]
43. A novel G protein-biased and subtype-selective agonist for a G pro.. [804]
44. Common activation mechanism of class A GPCRs [792]
45. Advancing Chemokine GPCR Structure Based Drug Discovery [779]
46. Virus Disinfection from Environmental Water Sources Using Living E.. [779]
47. Structural basis for activation of the growth hormone-releasing ho.. [777]
48. Intrinsically Disordered Proteins Link Alternative Splicing and Po.. [767]
49. A core epitope targeting antibody of SARS-CoV-2 [747]
50. Structural basis of ligand recognition and self-activation of orph.. [740]
51. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila [740]
52. Transition-Linker Containing Detergents for Membrane Protein Studi.. [681]
53. Ugi Reaction Mediated Detergent Assembly for Membrane Protein Stud.. [675]
54. Hybrid spectral library combining DIA-MS data and a targeted virtu.. [651]
55. Determination of the melanocortin-4 receptor structure identifies .. [650]
56. Cytoophidia coupling adipose architecture and metabolism [646]
57. Structures of the human cholecystokinin receptors bound to agonist.. [644]
58. Examination of the Deubiquitylation Site Selectivity of USP51 by U.. [634]
59. Structure-Activity Relationship Studies of Hydantoin-Cored Ligands.. [626]
60. Structure-Based Design of Melanocortin 4 Receptor Ligands Based on.. [622]
61. Molecular Basis for the Final Oxidative Rearrangement Steps in Cha.. [616]
62. Structure-Based Ligand Discovery Targeting the Transmembrane Domai.. [614]
63. Evaluation of chemical cross-linkers for in-depth structural analy.. [608]
64. Exploring the Mutational Robustness of Nucleic Acids by Searching .. [604]
65. A widespread pathway for substitution of adenine by diaminopurine .. [604]
66. G蛋白偶联受体的共同激活机制 [601]
67. Purification, characterization, and application of a high activity.. [597]
68. Programmable adenine deamination in bacteria using a Cas9-adenine-.. [577]
69. 人源大麻素受体CB2的晶体结构 [566]
70. Chemical-induced phase transition and global conformational reorga.. [563]
71. Identification of a Small Probe That Can Be Conjugated to Proteins.. [549]
72. 平滑受体配体及其应用 [542]
73. Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PC.. [541]
74. A computational evaluation of targeted oxidation strategy (TOS) fo.. [523]
75. Conjugated secondary 12 alpha-hydroxylated bile acids promote live.. [505]
76. Structure-Based Design of Dual-Acting Compounds Targeting Adenosin.. [497]
77. Affinity Mass Spectrometry-Based Fragment Screening Identified a N.. [495]
78. Catalytic-state structure and engineering of Streptococcus thermop.. [482]
79. Inactivity of YGL082W in vitro due to impairment of conformational.. [468]
80. Metabolic Reprogramming in Cancer Is Induced to Increase Proton Pr.. [467]
81. Identification and Characterization of the Biosynthetic Pathway of.. [465]
82. Building the Chordata Olfactory Receptor Database using more than .. [462]
83. The versatile binding landscape of the TAAR1 pocket for LSD and ot.. [459]
84. Development of Yin-Yang ligand for cannabinoid receptors [446]
85. Allosterically inhibited PFKL via prostaglandin E2 withholds gluco.. [431]
86. Association analysis between novel variants in LEPR gene and litte.. [418]
87. Furin cleavage sites naturally occur in coronaviruses [416]
88. Large-Scale Analysis of Bioactive Ligand Conformational Strain Ene.. [409]
89. The chordata olfactory receptor database [409]
90. A framework for Frizzled-G protein coupling and implications to th.. [402]
91. H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulat.. [400]
92. Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers o.. [390]
93. Orthogonally Engineered Albumin with Attenuated Macrophage Phagocy.. [373]
94. 噬菌体Z基因组生物合成通路的研究进展 [372]
95. Effects of novel variants in BMP15 gene on litter size in Mongolia.. [355]
96. Zero-shot prediction of mutation effects with multimodal deep repr.. [352]
97. Structure-Based Design of Melanocortin 4 Receptor Ligands based on.. [345]
98. A homogeneous high-throughput array for the detection and discrimi.. [343]
99. Alternative Z-genome biosynthesis pathway shows evolutionary progr.. [342]
100. Multi-state Modeling of GPCRs at Experimental Accuracy via PromptG.. [325]

下载量

1. Crystal Structure of the Human Cannabinoid Receptor CB2 [1217]
2. Genome-wide CRISPR screen identifies FAM49B as a key regulator of .. [780]
3. High-throughput identification of G protein-coupled receptor modul.. [752]
4. Structural Basis of the Diversity of Adrenergic Receptors [714]
5. A structurally guided dissection-then-evolution strategy for ligan.. [648]
6. Crystal Structure of the Human Cannabinoid Receptor CB1 [638]
7. Crystal structure of a constitutive active mutant of adenosine A(2.. [624]
8. Ligands of Adrenergic Receptors: A Structural Point of View [462]
9. Molecular Mechanism for Ligand Recognition and Subtype Selectivity.. [453]
10. Crystal structure of a multi-domain human smoothened receptor in c.. [398]
11. Structural insights into the committed step of bacterial phospholi.. [380]
12. Cryo-EM structures of orphan GPR21 signaling complexes [350]
13. Salvianolic acids from antithrombotic Traditional Chinese Medicine.. [348]
14. Salvianolic acids from antithrombotic Traditional Chinese Medicine.. [339]
15. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing .. [333]
16. G protein-coupled receptors: structure- and function-based drug di.. [321]
17. The unconventional activation of the muscarinic acetylcholine rece.. [297]
18. Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Si.. [287]
19. Discovery of Novel Allosteric Modulators Targeting an Extra-Helica.. [285]
20. The activation mechanism and antibody binding mode for orphan GPR2.. [247]
21. Structural basis for activation of the growth hormone-releasing ho.. [218]
22. A unique hormonal recognition feature of the human glucagon-like p.. [209]
23. MD Simulations Revealing Special Activation Mechanism of Cannabino.. [179]
24. Protein contact map prediction using multiple sequence alignment d.. [41]
25. The versatile binding landscape of the TAAR1 pocket for LSD and ot.. [26]
26. A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine .. [25]
27. Disulfide-Containing Detergents (DCDs) for the Structural Biology .. [18]
28. G蛋白偶联受体的共同激活机制 [18]
29. Structure-Based Ligand Discovery Targeting the Transmembrane Domai.. [18]
30. Determination of an underneath binding in the transmembrane domain.. [17]
31. Multi-state Modeling of GPCRs at Experimental Accuracy via PromptG.. [17]
32. Colocalization Strategy Unveils an Underside Binding Site in the T.. [16]
33. The chordata olfactory receptor database [16]
34. Crystal structures of agonist-bound human cannabinoid receptor CB1 [15]
35. Structural basis for strychnine activation of human bitter taste r.. [14]
36. Allosterically inhibited PFKL via prostaglandin E2 withholds gluco.. [14]
37. The structure-based traceless specific fluorescence labeling of th.. [13]
38. Crystal structure of the Frizzled 4 receptor in a ligand-free stat.. [11]
39. Chemical-induced phase transition and global conformational reorga.. [11]
40. Molecular Mechanism of Acetate Transport through the Acetate Chann.. [10]
41. Catalytic-state structure and engineering of Streptococcus thermop.. [10]
42. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Pol.. [9]
43. Purification, characterization, and application of a high activity.. [9]
44. A core epitope targeting antibody of SARS-CoV-2 [9]
45. Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes.. [9]
46. 平滑受体配体及其应用 [8]
47. Building the Chordata Olfactory Receptor Database using more than .. [8]
48. A framework for Frizzled-G protein coupling and implications to th.. [8]
49. Human GLP-1 receptor transmembrane domain structure in complex wit.. [7]
50. Development of Yin-Yang ligand for cannabinoid receptors [7]
51. Structural Basis for Apelin Control of the Human Apelin Receptor [6]
52. Cryo-EM structure of an activated GPR4-Gs signaling complex [6]
53. Advancing Chemokine GPCR Structure Based Drug Discovery [5]
54. A novel G protein-biased and subtype-selective agonist for a G pro.. [5]
55. Affinity Mass Spectrometry-Based Fragment Screening Identified a N.. [5]
56. Structure-Activity Relationship Studies of Hydantoin-Cored Ligands.. [5]
57. Ugi Reaction Mediated Detergent Assembly for Membrane Protein Stud.. [5]
58. Transition-Linker Containing Detergents for Membrane Protein Studi.. [5]
59. Rational Remodeling of Atypical Scaffolds for the Design of Photos.. [4]
60. Cytoophidia coupling adipose architecture and metabolism [4]
61. 噬菌体Z基因组生物合成通路的研究进展 [4]
62. Succinate-acetate permease from Citrobacter koseri is an anion cha.. [3]
63. Filamentation of asparagine synthetase in Saccharomyces cerevisiae [3]
64. Identification of natural products as novel ligands for the human .. [3]
65. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila [3]
66. Elucidation of Distinct Modular Assemblies of Smoothened Receptor .. [3]
67. 人源大麻素受体CB2的晶体结构 [3]
68. GPCRana: A web server for quantitative analysis of GPCR structures [3]
69. 脊索动物嗅觉受体基因命名法的发展 [3]
70. Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers o.. [3]
71. Zero-shot prediction of mutation effects with multimodal deep repr.. [3]
72. Examination of the Deubiquitylation Site Selectivity of USP51 by U.. [2]
73. Evaluation of chemical cross-linkers for in-depth structural analy.. [2]
74. Structural basis of ligand recognition and self-activation of orph.. [2]
75. Virus Disinfection from Environmental Water Sources Using Living E.. [2]
76. Hybrid spectral library combining DIA-MS data and a targeted virtu.. [2]
77. Structure-Based Design of Dual-Acting Compounds Targeting Adenosin.. [2]
78. Effects of novel variants in BMP15 gene on litter size in Mongolia.. [2]
79. Alternative Z-genome biosynthesis pathway shows evolutionary progr.. [2]
80. Peptide-Scaffolded Detergents for Membrane Protein Studies [2]
81. Exploring the Mutational Robustness of Nucleic Acids by Searching .. [1]
82. Intrinsically Disordered Proteins Link Alternative Splicing and Po.. [1]
83. Molecular Basis for the Final Oxidative Rearrangement Steps in Cha.. [1]
84. Common activation mechanism of class A GPCRs [1]
85. Inactivity of YGL082W in vitro due to impairment of conformational.. [1]
86. Activation and Signaling Mechanism Revealed by Cannabinoid Recepto.. [1]
87. The structural study of mutation-induced inactivation of human mus.. [1]
88. Determination of the melanocortin-4 receptor structure identifies .. [1]
89. Structural basis of CXC chemokine receptor 2 activation and signal.. [1]
90. Structure-Based Design of Melanocortin 4 Receptor Ligands Based on.. [1]
91. A widespread pathway for substitution of adenine by diaminopurine .. [1]
92. Association analysis between novel variants in LEPR gene and litte.. [1]
93. Identification and Characterization of the Biosynthetic Pathway of.. [1]
94. H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulat.. [1]
95. A homogeneous high-throughput array for the detection and discrimi.. [1]
96. 人源Apelin受体与天然配体Apelin的多肽类似物的复合物晶体结构 [1]
97. Orthogonally Engineered Albumin with Attenuated Macrophage Phagocy.. [1]
98. Conformational ensembles for protein structure prediction [1]