Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds

doi:10.1016/j.theriogenology.2022.12.005

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	Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds
	Wang, Yilin 1; Chi, Zhijiao 1; Jia, Shunan 1; Zhao, Suwen2 ; Cao, Guifang 3; Purev, Chimgee 4; Cang, Ming 1; Yu, Haiquan 1; Li, Xihe 1; Bao, Siqin 1; Liu, Yongbin 1; Wang, Jianguo 1; Tong, Bin 1
	2023-03-01
发表期刊	THERIOGENOLOGY; (IF:2.4[JCR-2023],2.5[5-Year])
ISSN	0093-691X
卷号	198 页码:1-11
DOI	10.1016/j.theriogenology.2022.12.005
摘要	Reproductive traits, such as ovulation rate and litter size, are important factors influencing the sheep industry. The bone morphogenetic protein 15 (BMP15) is a major gene affecting the reproductive traits in sheep, and multiple mutations in BMP15 gene could affect the ovulation rate and litter size in many sheep breeds, showing high breed specificity. However, identification of novel variations and seeking breed-specific markers associated with litter size in other sheep breeds are still important. In this study, we sequenced the BMP15 gene of Mongolia sheep, and 12 novel variants were detected by direct sequencing and whole-genome resequencing. Among them, the g.50985975 G > A polymorphism in intron and synonymous c.755 T > C (Leu252Pro) in exon 2 of BMP15 were significantly associated with the litter sizes of Mongolia ewes (P < 0.01 and P < 0.01, respectively), as well as the g.50988478C > A and g.50987863G > A in the promoter region of BMP15 were significantly associated with the litter sizes of Ujimqin ewes (P < 0.05 and P < 0.01, respectively). The c.755 T > C mutation is predicted to change the tertiary structure of BMP15. Our findings may provide potentially useful genetic markers for increasing litter size in sheep.
关键词	Association BMP15 Litter size Mongolia sheep Novel mutation Ujimqin sheep
学科门类	Small Animals ; Food Animals ; Animal Science and Zoology ; Equine
URL	查看原文
收录类别	SCOPUS
语种	英语
原始文献类型	Article
Scopus 记录号	2-s2.0-85143984460
来源库	SCOPUS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/286425
专题	iHuman研究所 iHuman研究所_PI研究组_赵素文组
作者单位	1.The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock,School of Life Sciences,Inner Mongolia University,Hohhot,China; 2.iHuman Institute,School of Life Science and Technology,ShanghaiTech University,Shanghai,China; 3.Department of Veterinary,Inner Mongolia Agricultural University,Hohhot,China; 4.Science Park of Ministry of Education,Culture and Science of Mongolia,Ulaanbaatar,Mongolia
推荐引用方式 GB/T 7714	Wang, Yilin,Chi, Zhijiao,Jia, Shunan,et al. Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds[J]. THERIOGENOLOGY;,2023,198:1-11.
APA	Wang, Yilin.,Chi, Zhijiao.,Jia, Shunan.,Zhao, Suwen.,Cao, Guifang.,...&Tong, Bin.(2023).Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds.THERIOGENOLOGY;,198,1-11.
MLA	Wang, Yilin,et al."Effects of novel variants in BMP15 gene on litter size in Mongolia and Ujimqin sheep breeds".THERIOGENOLOGY; 198(2023):1-11.