Structural basis of ligand recognition and self-activation of orphan GPR52

doi:10.1038/s41586-020-2019-0

	Structural basis of ligand recognition and self-activation of orphan GPR52
	Lin, Xi1,2,3,4 ; Li, Mingyue2,3,4 ; Wang, Niandong1,2,3,4 ; Wu, Yiran1 ; Luo, Zhipu 5; Guo, Shimeng 6; Han, Gye-Won 7; Li, Shaobai 8,9; Yue, Yang1 ; Wei, Xiaohu2,3,4 ; Xie, Xin2 ; Chen, Yong2,3,4 ; Zhao, Suwen1,2 ; Wu, Jian 8,9,10; Lei, Ming 8,9,11; Xu, Fei1,2,12
	2020-02-19
发表期刊	NATURE (IF:50.5[JCR-2023],54.4[5-Year])
ISSN	0028-0836
EISSN	1476-4687
发表状态	已发表
DOI	10.1038/s41586-020-2019-0
摘要	Structures of the orphan G-protein-coupled receptor GPR52 in ligand-free, G-protein-coupled and ligand-bound states reveal that extracellular loop 2 occupies the orthosteric binding pocket and functions as a built-in agonist to activate the receptor.
收录类别	SCI ; SCIE
资助项目	Shanghai Outstanding Academic Leader funding[19XD1422800]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000517050000006
出版者	NATURE PUBLISHING GROUP
WOS关键词	CRYO-EM STRUCTURE ; PROTEIN-COUPLED RECEPTORS ; BETA(2)-ADRENERGIC RECEPTOR ; CRYSTAL-STRUCTURE ; IONIC LOCK ; AGONIST ; DISCOVERY ; CRYSTALLIZATION ; STABILIZATION ; MUTAGENESIS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/114862
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_陈勇组生命科学与技术学院_特聘教授组_谢欣组 iHuman研究所_PI研究组_徐菲组 iHuman研究所_PI研究组_赵素文组生命科学与技术学院_硕士生
共同第一作者	Li, Mingyue; Wang, Niandong; Wu, Yiran
通讯作者	Wu, Jian; Lei, Ming; Xu, Fei
作者单位	1.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Soochow Univ, Sch Biol & Basic Med Sci, Inst Mol Enzymol, Suzhou, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai, Peoples R China 7.Univ Southern Calif, Bridge Inst, Dept Biol Sci, Los Angeles, CA USA 8.Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Shanghai, Peoples R China 9.Shanghai Inst Precis Med, Shanghai, Peoples R China 10.Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai, Peoples R China 11.Shanghai Jiao Tong Univ, Sch Med, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai, Peoples R China 12.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China
第一作者单位	iHuman研究所; 生命科学与技术学院
通讯作者单位	iHuman研究所; 生命科学与技术学院
第一作者的第一单位	iHuman研究所
推荐引用方式 GB/T 7714	Lin, Xi,Li, Mingyue,Wang, Niandong,et al. Structural basis of ligand recognition and self-activation of orphan GPR52[J]. NATURE,2020.
APA	Lin, Xi.,Li, Mingyue.,Wang, Niandong.,Wu, Yiran.,Luo, Zhipu.,...&Xu, Fei.(2020).Structural basis of ligand recognition and self-activation of orphan GPR52.NATURE.
MLA	Lin, Xi,et al."Structural basis of ligand recognition and self-activation of orphan GPR52".NATURE (2020).