A homogeneous high-throughput array for the detection and discrimination of influenza A viruses

doi:10.1016/j.chempr.2022.03.012

	A homogeneous high-throughput array for the detection and discrimination of influenza A viruses
	Dou, Wei-Tao 1,2; Wang, Xiang 3; Liu, Tingting4 ; Zhao, Suwen4,5 ; Liu, Jiao-Jiao 6; Yan, Yao 3; Li, Jun 3; Zhang, Chi-Yu 3; Sedgwick, Adam C.7; Tian, He ; Sessler, Jonathan L.7; Zhou, Dong-Ming 3,6; He, Xiao-Peng 1,2
	2022-06-09
发表期刊	CHEM (IF:19.1[JCR-2023],23.8[5-Year])
ISSN	2451-9294
卷号	8 期号:6
发表状态	已发表
DOI	10.1016/j.chempr.2022.03.012
摘要	The transmission of influenza A viruses (IAVs) from animal to human has resulted in a number of pandemics. Here, we report the synthesis of several sialyl-glycan-functionalized vibration-induced emissive probes (VIEgens V1-V10) that differ in their interaction with the relevant IAV hemagglutinin (HA). Collectively, V1-V10 provide a characteristic "fingerprint'' for different IAV subtypes. This differential sensing allowed the construction of a glycoVIEgen array that permits detection of IAVs and discrimination against other viral species; it also enables the determination of IAVs specific to individual species, including bird and human, as well as for more than one species. This array allowed preliminary assessments of adenovirus vaccines specific to a given IAV strain to be made. These results highlight the use of a VIEgen scaffold for differential sensing and as a diagnostic system that could find use in low-income "hotspot'' regions where early assessments of viral transmission between people, wildlife, and livestock are challenging.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[91853201,22107028] ; National Science and Technology Major Project of China[2018ZX10732202] ; Shanghai Municipal Science and TechnologyMajor Project[2018SHZDZX03] ; Fundamental Research Funds for the Central Universities[222201717003] ; National Postdoctoral Program for Innovative Talents[BX20190115] ; Shanghai Post-doctoral Excellence Program[2019044] ; China Postdoctoral Science Foundation[2020M681206] ; Robert A. Welch Foundation[F-0018]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000814056500004
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/197848
专题	iHuman研究所_PI研究组_赵素文组生命科学与技术学院
通讯作者	Sessler, Jonathan L.; Zhou, Dong-Ming; He, Xiao-Peng
作者单位	1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Key L, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Joint, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Vaccine & Immun Res Ctr, Shanghai 201508, Peoples R China 4.ShanghaiTech Univ, iHuman Inst, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 6.Tianjin Med Univ, Sch Basic Med Sci, Dept Pathogen Biol, Tianjin 300070, Peoples R China 7.Univ Texas Austin, Dept Chem, Austin, TX 78712 USA
推荐引用方式 GB/T 7714	Dou, Wei-Tao,Wang, Xiang,Liu, Tingting,et al. A homogeneous high-throughput array for the detection and discrimination of influenza A viruses[J]. CHEM,2022,8(6).
APA	Dou, Wei-Tao.,Wang, Xiang.,Liu, Tingting.,Zhao, Suwen.,Liu, Jiao-Jiao.,...&He, Xiao-Peng.(2022).A homogeneous high-throughput array for the detection and discrimination of influenza A viruses.CHEM,8(6).
MLA	Dou, Wei-Tao,et al."A homogeneous high-throughput array for the detection and discrimination of influenza A viruses".CHEM 8.6(2022).