Furin cleavage sites naturally occur in coronaviruses

doi:10.1016/j.scr.2020.102115

	Furin cleavage sites naturally occur in coronaviruses
	Wu, Yiran1 ; Zhao, Suwen1,2
	2021-01
发表期刊	STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN	1873-5061
EISSN	1876-7753
卷号	50 页码:#VALUE!
DOI	10.1016/j.scr.2020.102115
摘要	The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology
WOS记录号	WOS:000614260000007
出版者	ELSEVIER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125924
专题	iHuman研究所_PI研究组_赵素文组生命科学与技术学院
通讯作者	Wu, Yiran
作者单位	1.Shanghai Tech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	上海科技大学
通讯作者单位	上海科技大学
第一作者的第一单位	上海科技大学
推荐引用方式 GB/T 7714	Wu, Yiran,Zhao, Suwen. Furin cleavage sites naturally occur in coronaviruses[J]. STEM CELL RESEARCH,2021,50:#VALUE!.
APA	Wu, Yiran,&Zhao, Suwen.(2021).Furin cleavage sites naturally occur in coronaviruses.STEM CELL RESEARCH,50,#VALUE!.
MLA	Wu, Yiran,et al."Furin cleavage sites naturally occur in coronaviruses".STEM CELL RESEARCH 50(2021):#VALUE!.