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成果统计

合作作者[TOP 5]

  • 华甜

    合作成果数：44

  • Wang, BC

    合作成果数：36

  • Shaw, Neil

    合作成果数：31

  • 合作成果数：25

  • Wang, Bi-Cheng

    合作成果数：22

访问统计


  总访问量
 9499
  访问来源
    内部： 563
    外部： 8936
    国内： 8805
    国外： 694

  年访问量
 480
  访问来源
    内部： 3
    外部： 477
    国内： 454
    国外： 26

  月访问量
 201
  访问来源
    内部： 3
    外部： 198
    国内： 190
    国外： 11

访问量

访问量

1. The emerging roles of the DDX41 protein in immunity and diseases [9310]
2. In vitro expression and analysis of the 826 human G protein-couple.. [9252]
3. Crystal Structure of the Human Cannabinoid Receptor CB2 [5588]
4. Structural analysis of asparaginyl endopeptidase reveals the activ.. [3604]
5. Structure of the RNA-dependent RNA polymerase from COVID-19 virus [3189]
6. High-throughput identification of G protein-coupled receptor modul.. [2716]
7. Elucidating the active delta-opioid receptor crystal structure wit.. [2627]
8. Crystal Structure of the Human Cannabinoid Receptor CB1 [2513]
9. Structural Basis of the Diversity of Adrenergic Receptors [2426]
10. Crystal structures of the F88Y obelin mutant before and after biol.. [2085]
11. Structural basis for DNA recognition by STAT6 [1912]
12. New insights into the structural basis of DNA recognition by HINa .. [1843]
13. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase [1753]
14. Protein crystal quality oriented disulfide bond engineering [1712]
15. Molecular insights into ligand recognition and G protein coupling .. [1680]
16. Native phasing of x-ray free-electron laser data for a G protein-c.. [1624]
17. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperth.. [1588]
18. Molecular Mechanism for Ligand Recognition and Subtype Selectivity.. [1581]
19. Biochemical features of the adhesion G protein-coupled receptor CD.. [1570]
20. Crystal structures of agonist-bound human cannabinoid receptor CB1 [1417]
21. Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynam.. [1416]
22. Organized cannabinoid receptor distribution in neurons revealed by.. [1410]
23. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Pol.. [1376]
24. Structural insights into the activation initiation of full-length .. [1361]
25. Structural basis for strychnine activation of human bitter taste r.. [1220]
26. All Ca2+-binding loops of light-sensitive ctenophore photoprotein .. [1188]
27. Identification of natural products as novel ligands for the human .. [1160]
28. Human GLP-1 receptor transmembrane domain structure in complex wit.. [1159]
29. Disulfide-Containing Detergents (DCDs) for the Structural Biology .. [1113]
30. Molecular Mechanism of Acetate Transport through the Acetate Chann.. [1111]
31. Ligand identification of the adenosine A(2A) receptor in self-asse.. [1106]
32. Crystal structure of hGEF-H1 PH domain provides insight into incap.. [1101]
33. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and it.. [1100]
34. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug .. [1098]
35. Structural basis of CXC chemokine receptor 2 activation and signal.. [1072]
36. Functionality-Independent DNA Encoding of Complex Natural Products [1041]
37. Prediction of disulfide bond engineering sites using a machine lea.. [1037]
38. Computational design of thermostabilizing point mutations for G pr.. [973]
39. MD Simulations Revealing Special Activation Mechanism of Cannabino.. [967]
40. Crystal structure of the N-terminal methyltransferase-like domain .. [940]
41. Self-capping of nucleoprotein filaments protects the Newcastle dis.. [938]
42. Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique C.. [931]
43. Structural basis of G protein couple receptor polypharmacology [901]
44. A Chemical Strategy for Amphiphile Replacement in Membrane Protein.. [896]
45. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Eff.. [874]
46. Novel Functionalized Cannabinoid Receptor Probes: Development of E.. [856]
47. Structural and Functional Insights into Cannabinoid Receptors [854]
48. Three-dimensional structures of mutants of Ca2+-regulated photopro.. [845]
49. Crystal structure of semisynthetic obelin-v [843]
50. Activation and Signaling Mechanism Revealed by Cannabinoid Recepto.. [837]
51. The structural study of mutation-induced inactivation of human mus.. [836]
52. Rational Remodeling of Atypical Scaffolds for the Design of Photos.. [828]
53. High-resolution relaxometry-based calibrated fMRI in murine brain:.. [825]
54. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant .. [811]
55. A novel G protein-biased and subtype-selective agonist for a G pro.. [804]
56. Common activation mechanism of class A GPCRs [792]
57. Exploring a new ligand binding site of G proteincoupled receptors [786]
58. A combined cerebral blood flow method with R2 prime for calibrated.. [785]
59. Structural insight into the constitutive activity of human orphan .. [777]
60. Structural basis of selective cannabinoid CB2 receptor activation [777]
61. Two-Dimensional Detergent Expansion Strategy for Membrane Protein .. [775]
62. Mitrocomin from the jellyfish Mitrocoma cellularia with deleted C-.. [771]
63. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regul.. [746]
64. Activation and allosteric modulation of muscarinic acetylcholine M.. [743]
65. Structural biology study of human cannabinoid receptors [732]
66. Hydrogen bond network near OH group of 6-(p-hydroxyphenyl) substit.. [722]
67. Explore novel JNK3 ligand by HTS of designed scaffold library usin.. [711]
68. Structural features of activated GPCR signaling complexes [708]
69. Structural insights into the activation of chemokine receptor CXCR.. [694]
70. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modula.. [692]
71. 一种基于喹诺酮结构的光控配体及其应用 [688]
72. Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Ass.. [665]
73. Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a.. [655]
74. Carbon-silicon switch led to the discovery of novel synthetic cann.. [654]
75. 揭开苦味受体的神秘"面纱" [654]
76. 一种噻吩并哒嗪酮类化合物、含其的药物组合物、其制备方法及其应用 [623]
77. 人源大麻素受体CB2的晶体结构 [566]
78. SYSTEMS AND METHODS FOR ELECTRON CRYOTOMOGRAPHY RECONSTRUCTION [564]
79. 一种大麻素类化合物，其制备方法、组合物和用途 [560]
80. 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用 [553]
81. NEURAL IMPLICIT FUNCTION FOR END-TO-END RECONSTRUCTION OF DYNAMIC .. [540]
82. Unlocking TAS2R14 activation through intricate multi-ligand bindin.. [527]
83. 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用 [514]
84. Bitter taste TAS2R14 activation by intracellular tastants and chol.. [500]
85. 人源大麻素受体的结构生物学研究 [498]
86. 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用 [489]
87. 五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础 [481]
88. 趋化因子受体的结构与信号转导机制 [470]
89. 人源大麻素受体CB1晶体结构 [469]
90. 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用 [468]
91. 皮肤癌中转化生长因子-β信号通路研究进展 [431]
92. 昙花提取物及其在调控多巴胺受体通路中的应用 [428]
93. Structural basis of antagonist selectivity in endothelin receptors [421]
94. The chordata olfactory receptor database [409]
95. 发展亲和质谱技术高通量筛选G-蛋白偶联受体的调节剂 [407]
96. 昙花提取物在调控皮肤节律相关通路中的应用 [405]
97. Architecture of CTPS filament networks revealed by cryo-electron t.. [395]
98. 刘志杰：大道不孤，揭开膜受体结构之谜 [377]
99. 褪黑素在调控CRY1和PER2基因表达中的应用 [372]
100. Structural insights into the high basal activity and inverse agoni.. [247]

下载量

1. The emerging roles of the DDX41 protein in immunity and diseases [2021]
2. In vitro expression and analysis of the 826 human G protein-couple.. [1657]
3. Elucidating the active delta-opioid receptor crystal structure wit.. [1378]
4. Crystal Structure of the Human Cannabinoid Receptor CB2 [1217]
5. High-throughput identification of G protein-coupled receptor modul.. [752]
6. Structural Basis of the Diversity of Adrenergic Receptors [714]
7. Structural analysis of asparaginyl endopeptidase reveals the activ.. [695]
8. Crystal Structure of the Human Cannabinoid Receptor CB1 [638]
9. Structure of the RNA-dependent RNA polymerase from COVID-19 virus [611]
10. Crystal structures of the F88Y obelin mutant before and after biol.. [455]
11. Molecular Mechanism for Ligand Recognition and Subtype Selectivity.. [453]
12. New insights into the structural basis of DNA recognition by HINa .. [407]
13. Protein crystal quality oriented disulfide bond engineering [401]
14. Molecular insights into ligand recognition and G protein coupling .. [396]
15. Biochemical features of the adhesion G protein-coupled receptor CD.. [380]
16. Structural basis for DNA recognition by STAT6 [376]
17. Organized cannabinoid receptor distribution in neurons revealed by.. [340]
18. Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynam.. [334]
19. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperth.. [318]
20. Native phasing of x-ray free-electron laser data for a G protein-c.. [314]
21. Structural insights into the activation initiation of full-length .. [311]
22. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Eff.. [292]
23. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and it.. [271]
24. Prediction of disulfide bond engineering sites using a machine lea.. [261]
25. MD Simulations Revealing Special Activation Mechanism of Cannabino.. [179]
26. Structural basis of selective cannabinoid CB2 receptor activation [173]
27. Unlocking TAS2R14 activation through intricate multi-ligand bindin.. [73]
28. Bitter taste TAS2R14 activation by intracellular tastants and chol.. [25]
29. Ligand identification of the adenosine A(2A) receptor in self-asse.. [22]
30. Functionality-Independent DNA Encoding of Complex Natural Products [21]
31. Disulfide-Containing Detergents (DCDs) for the Structural Biology .. [18]
32. The chordata olfactory receptor database [16]
33. Architecture of CTPS filament networks revealed by cryo-electron t.. [16]
34. Crystal structures of agonist-bound human cannabinoid receptor CB1 [15]
35. Structural basis of antagonist selectivity in endothelin receptors [15]
36. Structural basis for strychnine activation of human bitter taste r.. [14]
37. Structural insights into the high basal activity and inverse agoni.. [12]
38. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug .. [11]
39. Molecular Mechanism of Acetate Transport through the Acetate Chann.. [10]
40. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Pol.. [9]
41. Structural basis of G protein couple receptor polypharmacology [9]
42. 一种噻吩并哒嗪酮类化合物、含其的药物组合物、其制备方法及其应用 [9]
43. Crystal structure of hGEF-H1 PH domain provides insight into incap.. [8]
44. Self-capping of nucleoprotein filaments protects the Newcastle dis.. [8]
45. Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a.. [8]
46. Two-Dimensional Detergent Expansion Strategy for Membrane Protein .. [8]
47. Human GLP-1 receptor transmembrane domain structure in complex wit.. [7]
48. 昙花提取物及其在调控多巴胺受体通路中的应用 [7]
49. Activation and allosteric modulation of muscarinic acetylcholine M.. [6]
50. A Chemical Strategy for Amphiphile Replacement in Membrane Protein.. [6]
51. Structural insight into the constitutive activity of human orphan .. [6]
52. 昙花提取物在调控皮肤节律相关通路中的应用 [6]
53. 稠杂环类化合物与其制备方法、药物组合物及应用 [6]
54. 一种自动化细胞表达重组蛋白的设备 [6]
55. CryoGEM: Physics-Informed Generative Cryo-Electron Microscopy [6]
56. A novel G protein-biased and subtype-selective agonist for a G pro.. [5]
57. Computational design of thermostabilizing point mutations for G pr.. [4]
58. Exploring a new ligand binding site of G proteincoupled receptors [4]
59. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase [4]
60. Rational Remodeling of Atypical Scaffolds for the Design of Photos.. [4]
61. Crystal structure of semisynthetic obelin-v [4]
62. 褪黑素在调控CRY1和PER2基因表达中的应用 [4]
63. Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex [4]
64. Explore novel JNK3 ligand by HTS of designed scaffold library usin.. [3]
65. Structural biology study of human cannabinoid receptors [3]
66. Identification of natural products as novel ligands for the human .. [3]
67. 人源大麻素受体CB2的晶体结构 [3]
68. 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用 [3]
69. 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用 [3]
70. All Ca2+-binding loops of light-sensitive ctenophore photoprotein .. [2]
71. Crystal structure of the N-terminal methyltransferase-like domain .. [2]
72. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant .. [2]
73. Mitrocomin from the jellyfish Mitrocoma cellularia with deleted C-.. [2]
74. Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique C.. [2]
75. Structural and Functional Insights into Cannabinoid Receptors [2]
76. 一种基于喹诺酮结构的光控配体及其应用 [2]
77. Carbon-silicon switch led to the discovery of novel synthetic cann.. [2]
78. Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Ass.. [2]
79. 趋化因子受体的结构与信号转导机制 [2]
80. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regul.. [1]
81. Common activation mechanism of class A GPCRs [1]
82. Activation and Signaling Mechanism Revealed by Cannabinoid Recepto.. [1]
83. The structural study of mutation-induced inactivation of human mus.. [1]
84. Structural basis of CXC chemokine receptor 2 activation and signal.. [1]
85. Structural features of activated GPCR signaling complexes [1]
86. Novel Functionalized Cannabinoid Receptor Probes: Development of E.. [1]
87. 一种大麻素类化合物，其制备方法、组合物和用途 [1]
88. Structural insights into the activation of chemokine receptor CXCR.. [1]
89. High-resolution relaxometry-based calibrated fMRI in murine brain:.. [1]
90. 人源大麻素受体的结构生物学研究 [1]
91. 五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础 [1]
92. 人源大麻素受体CB1晶体结构 [1]
93. 皮肤癌中转化生长因子-β信号通路研究进展 [1]
94. 刘志杰：大道不孤，揭开膜受体结构之谜 [1]