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ShanghaiTech University Knowledge Management System
| Structural features of activated GPCR signaling complexes | |
| 2020-08 | |
| 发表期刊 | CURRENT OPINION IN STRUCTURAL BIOLOGY (IF:6.1[JCR-2023],6.0[5-Year]) |
| ISSN | 0959-440X |
| EISSN | 1879-033X |
| 卷号 | 63页码:82-89 |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.sbi.2020.04.008 |
| 摘要 | G protein-coupled receptors (GPCRs) couple to diverse heterotrimeric G protein subtypes and then activate downstream signaling pathways in classical GPCR activation. It has also been found that GPCRs transduce signals through different regulatory proteins, such as arrestins. Recently, owing to the breakthroughs in cryo-electron macroscopy (Cryo-EM), numerous structures of GPCR-G protein or GPCR-arrestin complexes have been deciphered. In this review, we summarize most of reported GPCR signaling complex structures, with an emphasis on the structural features of rhodopsin-like GPCR activation and G protein-binding/ arrestin-binding modes, to illustrate the activation and signaling mechanism of rhodopsin-like GPCRs. |
| 收录类别 | SCI ; SCIE |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31930060][31870744] ; National Key Research and Development Program of China[2018YFA0507000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS记录号 | WOS:000565166700013 |
| 出版者 | CURRENT BIOLOGY LTD |
| WOS关键词 | CRYO-EM STRUCTURE ; PROTEIN-COUPLED RECEPTORS ; CRYSTAL-STRUCTURE ; GLP-1 RECEPTOR ; ARRESTIN ; DETERMINANTS ; RHODOPSIN ; MECHANISM ; HIGHLIGHT |
| 原始文献类型 | Review |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123179 |
| 专题 | 生命科学与技术学院_博士生 iHuman研究所_PI研究组_刘志杰组 iHuman研究所_PI研究组_华甜组 |
| 通讯作者 | Hua, Tian; Liu, Zhi-Jie |
| 作者单位 | 1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 第一作者单位 | iHuman研究所; 生命科学与技术学院 |
| 通讯作者单位 | iHuman研究所; 生命科学与技术学院 |
| 第一作者的第一单位 | iHuman研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Jingjing,Hua, Tian,Liu, Zhi-Jie. Structural features of activated GPCR signaling complexes[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2020,63:82-89. |
| APA | Wang, Jingjing,Hua, Tian,&Liu, Zhi-Jie.(2020).Structural features of activated GPCR signaling complexes.CURRENT OPINION IN STRUCTURAL BIOLOGY,63,82-89. |
| MLA | Wang, Jingjing,et al."Structural features of activated GPCR signaling complexes".CURRENT OPINION IN STRUCTURAL BIOLOGY 63(2020):82-89. |
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