The emerging roles of the DDX41 protein in immunity and diseases
Jiang, Yan1; Zhu, Yanping1; Liu, Zhi-Jie1,2; Ouyang, Songying1,3
2017-02
Source PublicationPROTEIN & CELL
ISSN1674-800X
Volume8Issue:2Pages:83-89
DOI10.1007/s13238-016-0303-4
AbstractRNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box helicases comprise the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recent literatures on one member of the SF2 superfamily, the DEAD-box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons (IFN). After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (MDS/AML) patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survival at all stages throughout the life cycle of the fly.
KeywordDDX41 innate immunity RNA helicases myelodysplastic syndrome acute myeloid leukemia
Indexed BySCI
Language英语
Funding ProjectYouth Innovation Promotion Association CAS[2013065]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000394146000002
PublisherHIGHER EDUCATION PRESS
WOS KeywordDEAD-BOX PROTEIN ; CYCLIC DI-GMP ; ACUTE MYELOID-LEUKEMIA ; STING ADAPTER PROTEIN ; DENDRITIC CELLS ; RNA HELICASES ; I-TASSER ; REPLICATION ; MUTATIONS ; ABSTRAKT
Original Document TypeReview
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1057
CollectioniHuman研究所_PI研究组_刘志杰组
iHuman研究所
Corresponding AuthorOuyang, Songying
Affiliation1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
2.Shanghai Tech Univ, iHuman Inst, Shanghai 201210, Peoples R China
3.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
Recommended Citation
GB/T 7714
Jiang, Yan,Zhu, Yanping,Liu, Zhi-Jie,et al. The emerging roles of the DDX41 protein in immunity and diseases[J]. PROTEIN & CELL,2017,8(2):83-89.
APA Jiang, Yan,Zhu, Yanping,Liu, Zhi-Jie,&Ouyang, Songying.(2017).The emerging roles of the DDX41 protein in immunity and diseases.PROTEIN & CELL,8(2),83-89.
MLA Jiang, Yan,et al."The emerging roles of the DDX41 protein in immunity and diseases".PROTEIN & CELL 8.2(2017):83-89.
Files in This Item: Download All
File Name/Size DocType Version Access License
10.1007@s13238-016-0(2511KB)期刊论文出版稿开放获取CC BYView Download
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Jiang, Yan]'s Articles
[Zhu, Yanping]'s Articles
[Liu, Zhi-Jie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jiang, Yan]'s Articles
[Zhu, Yanping]'s Articles
[Liu, Zhi-Jie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jiang, Yan]'s Articles
[Zhu, Yanping]'s Articles
[Liu, Zhi-Jie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.1007@s13238-016-0303-4.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.