Recent development of AAV-based gene therapies for inner ear disorders
Lan, Yiyang1,2; Tao, Yong3; Wang, Yunfeng4,5; Ke, Junzi1,2; Yang, Qiuxiang1,2; Liu, Xiaoyi1,2; Su, Bing1,2; Wu, Yiling2; Lin, Chao-Po2; Zhong, Guisheng1,2
2020-05-18
Source PublicationGENE THERAPY
ISSN0969-7128
EISSN1476-5462
Status已发表
DOI10.1038/s41434-020-0155-7
AbstractGene therapy for auditory diseases is gradually maturing. Recent progress in gene therapy treatments for genetic and acquired hearing loss has demonstrated the feasibility in animal models. However, a number of hurdles, such as lack of safe viral vector with high efficiency and specificity, robust deafness large animal models, translating animal studies to clinic etc., still remain to be solved. It is necessary to overcome these challenges in order to effectively recover auditory function in human patients. Here, we review the progress made in our group, especially our efforts to make more effective and cell type-specific viral vectors for targeting cochlea cells.
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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81970878][31771130]
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS SubjectBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS IDWOS:000533843300001
PublisherNATURE PUBLISHING GROUP
WOS KeywordADENOASSOCIATED VIRUS VECTORS ; MOUSE MODEL ; HAIR-CELLS ; SUPPORTING CELLS ; PROTEIN EXPRESSION ; HEARING-LOSS ; IN-VITRO ; MAMMALIAN COCHLEA ; TRANSDUCTION ; MUTATIONS
Original Document TypeReview ; Early Access
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121134
Collection生命科学与技术学院_硕士生
生命科学与技术学院_PI研究组_林照博组
iHuman研究所_PI研究组_钟桂生组
生命科学与技术学院_本科生
Corresponding AuthorZhong, Guisheng
Affiliation1.ShanghaiTech Univ, IHuman Inst, Shanghai 201210, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Otolaryngol Head & Neck Surg, Sch Med, Shanghai 200011, Peoples R China
4.Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China
5.Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
First Author AffilicationiHuman Institute;  School of Life Science and Technology
Corresponding Author AffilicationiHuman Institute;  School of Life Science and Technology
First Signature AffilicationiHuman Institute
Recommended Citation
GB/T 7714
Lan, Yiyang,Tao, Yong,Wang, Yunfeng,et al. Recent development of AAV-based gene therapies for inner ear disorders[J]. GENE THERAPY,2020.
APA Lan, Yiyang.,Tao, Yong.,Wang, Yunfeng.,Ke, Junzi.,Yang, Qiuxiang.,...&Zhong, Guisheng.(2020).Recent development of AAV-based gene therapies for inner ear disorders.GENE THERAPY.
MLA Lan, Yiyang,et al."Recent development of AAV-based gene therapies for inner ear disorders".GENE THERAPY (2020).
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