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TNFR2/CCR8 bispecific antibody enhances antitumor activity through depleting Ti-Tregs and boosting effector CD8
+
T cell function
期刊论文
ONCOIMMUNOLOGY, 2025, 卷号: 14, 期号: 1
Authors:
Wang, Ran
;
Xu, Jiefang
;
Cheng, Shipeng
;
Ling, Zhiyang
;
Sonam, Wangmo
Adobe PDF(5792Kb)
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View/Download:11/1
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Submit date:2025/05/12
FT10-Fab
TNFR2
CCR8
Ti-Tregs
CD8(+) T cell
antitumour
immunotherapy
A powerful and highly efficient PAI-mediated transgenesis approach in Drosophila
期刊论文
NUCLEIC ACIDS RESEARCH, 2025, 卷号: 53, 期号: 8
Authors:
Shi, Wangfei
;
Zhang, Xuedi
;
Sun, Angyang
;
Zheng, Jie
;
Zhuang, Kailong
Adobe PDF(2244Kb)
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Submit date:2025/05/06
一种氘代喜树碱衍生物及其制备方法与用途
专利
申请号:CN202510102451.4,申请日期: 2025-05-02,类型:发明申请,状态:实质审查
Inventors:
姜标
;
陈红莉
;
于宪强
;
孙紫煜
Adobe PDF(1313Kb)
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Submit date:2025/05/02
Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis
期刊论文
NATURE METABOLISM, 2025, 卷号: -, 期号: -, 页码: -
Authors:
Xu, Mengqiang
;
Jiang, Shiyou
;
Tang, Shuocheng
;
Zhu, Meimei
;
Hu, Yueer
Adobe PDF(942Kb)
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  |  
Submit date:2025/04/02
SREBP
nuclear condensate
super-enhancer
BRD4
H3K27Ac
lipid synthesis
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method
期刊论文
ACTA PHARMACOLOGICA SINICA, 2025
Authors:
Wang, Shi-hang
;
Zeng, Yue
;
Yang, Hao
;
Tian, Si-yuan
;
Zhou, Yong-qi
Favorite
  |  
View/Download:5/0
  |  
Submit date:2025/05/20
N
-methyl-
D
-aspartate receptors
GluN1/GluN3A
ligand-based virtual screening
scaffold hopping
deep learning
GeminiMol
Structure and mechanism of a mycobacterial isoniazid efflux pump
Ms
Rv1273c/72c with a degenerate nucleotide-binding site
期刊论文
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1
Authors:
Yu, Jing
;
Lan, Yuhui
;
Zhu, Chen
;
Chen, Zhendong
;
Pan, Junyi
Adobe PDF(5650Kb)
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Submit date:2025/05/12
Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness
期刊论文
NEURON, 2025
Authors:
Simeng Zhao
;
Qiuxiang Yang
;
Zehua Yu
;
Cenfeng Chu
;
Shengqi Dai
Adobe PDF(9318Kb)
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  |  
Submit date:2025/05/12
hereditary hearing loss
gene therapy
adeno-associated viruses
AAVs
outer hair cell
OHC
Slc26a5
transcriptional enhancer
conserved non-coding elements
CNEs
Structural and Energetic Insights into SARS-CoV-2 Evolution: Analysis of hACE2-RBD Binding in Wild-Type, Delta, and Omicron Subvariants
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 卷号: 26, 期号: 8
Authors:
Tang, Can
;
Lupala, Cecylia S.
;
Wang, Ding
;
Li, Xiangcheng
;
Tang, Lei-Han
Adobe PDF(4612Kb)
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Submit date:2025/05/12
SARS-CoV-2
RBD-variants
molecular dynamics
binding strength
Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 14
Authors:
Din, Hengwei
;
Liu, Zixin
;
Mou, Dialing
;
Tang, Muxue
;
Huang, Xiuzhen
Adobe PDF(7831Kb)
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Submit date:2025/04/28
neuromesodermal progenitors
Sox2
brachyury
potent progenitors
dual genetic lineage tracing
Establishing a High-Yield
Bacillus subtilis
-Based Cell-Free Protein Synthesis System for In Vitro Prototyping and Natural Product Biosynthesis
期刊论文
ACS SYNTHETIC BIOLOGY, 2025
Authors:
Ji, Xiangyang
;
Liu, Wan-Qiu
;
Cao, Zhiling
;
Huang, Shuhui
;
Li, Jian
Adobe PDF(2808Kb)
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View/Download:17/2
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Submit date:2025/04/20
cell-free protein synthesis
T7 RNA polymerase
Bacillus subtilis
genetic part prototyping
natural product biosynthesis
synthetic biology