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成果统计

合作作者[TOP 5]

  • 杨小宝

    合作成果数：96

  • 任超伟

    合作成果数：80

  • 孙宁

    合作成果数：71

  • 孙仁红

    合作成果数：52

  • 宋肖玲

    合作成果数：41

访问统计


  总访问量
 5415
  访问来源
    内部： 89
    外部： 5326
    国内： 4942
    国外： 473

  年访问量
 569
  访问来源
    内部： 2
    外部： 567
    国内： 538
    国外： 31

  月访问量
 6
  访问来源
    内部： 0
    外部： 6
    国内： 5
    国外： 1

访问量

访问量

1. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiti.. [3103]
2. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase [1790]
3. Zika virus infects renal proximal tubular epithelial cells with pr.. [1426]
4. Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRA.. [1192]
5. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug .. [1134]
6. Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prod.. [1120]
7. KPT330 improves Cas9 precision genome- and base-editing by selecti.. [1074]
8. Structural plasticity of green fluorescent protein to amino acid d.. [957]
9. Decision tree searching strategy to boost the identification of cr.. [935]
10. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Usin.. [904]
11. An electron transfer path connects subunits of a mycobacterial res.. [873]
12. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Ki.. [842]
13. AXL promotes Zika virus infection in astrocytes by antagonizing ty.. [840]
14. Structure-based discovery of dual pathway inhibitors for SARS-CoV-.. [816]
15. 低氘水的用途及相关产品 [805]
16. N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugat.. [786]
17. LLDT-288, a novel triptolide analogue exhibits potent antitumor ac.. [770]
18. Discovery and characterization of novel potent BCR-ABL degraders b.. [770]
19. Inhibition of mitochondrial complex III induces differentiation in.. [720]
20. The PROTAC selectively degrading Bcl-x(L) represents a novel Hedge.. [718]
21. Identification of a diverse synthetic abietane diterpenoid library.. [712]
22. Selective lysine modification of native peptides via aza-Michael a.. [697]
23. Two novel strategies to overcome the resistance to ALK tyrosine ki.. [690]
24. Combretastatin A4-derived payloads for antibody-drug conjugates [683]
25. Antibody-Drug Conjugates [680]
26. N-Phenyl-N-aceto-vinylsulfonamides as Efficient and Chemoselective.. [660]
27. Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived pept.. [650]
28. Development of a Brigatinib degrader (SIAIS117) as a potential tre.. [649]
29. A novel mass spectrometry-cleavable, phosphate-based enrichable an.. [642]
30. Novel strategies to target EGFR proteins for degradation and their.. [636]
31. Tris(2-carboxyethyl)phosphine promotes hydrolysis of iminoboronate.. [635]
32. Reactive oxygen species-responsive Pre-PROTAC for tumor-specific p.. [632]
33. Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bon.. [631]
34. A facile and efficient transposon mutagenesis method for generatio.. [625]
35. Inhibition of Neuroinflammation by Synthetic Androstene Derivative.. [622]
36. PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, .. [616]
37. Accessible Method for the Development of Novel Sterol Analogues wi.. [614]
38. ALK PROTEIN REGULATOR AND ANTI-TUMOR APPLICATION THEREOF [614]
39. PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, .. [610]
40. Bis(vinylsulfonyl)piperazines as efficient linkers for highly homo.. [603]
41. Protein degradation targeting compound, anti-tumor application, .. [592]
42. 一种调控剂及修复细胞辐射损伤的用途 [589]
43. A Concise Formal Synthesis of (-)-Hamigeran B [579]
44. Applications of macrocyclic molecules in cancer therapy: Target ca.. [570]
45. H2O-Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reaction.. [563]
46. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Met.. [563]
47. Divinylsulfonamides enable the construction of homogeneous antibod.. [559]
48. 基于NAMPT靶蛋白的蛋白降解化合物及其应用 [555]
49. Development of a MMAE-based antibody-drug conjugate targeting B7-H.. [553]
50. Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Contr.. [552]
51. Photoactivatable Fluorogenic Labeling via Turn-On "Click-Like" Nit.. [544]
52. Structure-based discovery of SIAIS001 as an oral bioavailability A.. [538]
53. 基于戊二酰亚胺骨架的化合物及其应用 [538]
54. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase.. [537]
55. A functional SNP rs895819 on pre-miR-27a is associated with bipola.. [517]
56. Phenyldivinylsulfonamides for the construction of antibody–drug c.. [513]
57. Effective degradation of EGFR(L858R+T790M) mutant proteins by CRBN.. [510]
58. 局部组合物和用途 [510]
59. Construction of an IMiD-based azide library as a kit for PROTAC re.. [502]
60. Chemical reagents for the enrichment of modified peptides in MS-ba.. [498]
61. PROTEIN DEGRADATION TARGETING BCR-ABL COMPOUND AND ANTITUMOR APPLI.. [497]
62. 一类多靶向交联剂及其制备与应用 [487]
63. A mild phenoxysilyl linker for self-immolative release of antibody.. [485]
64. 局部组合物及用途 [483]
65. Micropillar-based phenotypic screening platform uncovers involveme.. [481]
66. 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用 [479]
67. 一种基于磷酸富集的click试剂 [478]
68. 一种交联剂及其制备与在质谱交联技术中的应用 [474]
69. Site-specific construction of triptolide-based antibody-drug conju.. [469]
70. Utilization of macrocyclic peptides to target protein-protein inte.. [468]
71. EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF [466]
72. 局部组合物及用途。 [463]
73. CAS蛋白抑制剂的组合物及应用 [459]
74. TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEI.. [451]
75. COMPOUNDS TARGETING AND DEGRADING BCR-ABL PROTEIN AND ITS ANTITUMO.. [449]
76. 一种包括Nafamostat和K777的药物组合及其应用 [449]
77. Targeting Bcl-xL is a potential therapeutic strategy for extranoda.. [443]
78. ALK蛋白降解剂及其在癌症治疗中的用途 [442]
79. COMPOSITION AND USE OF CAS PROTEIN INHIBITORS [440]
80. 基于戊二酰亚胺骨架的化合物及其应用 [433]
81. 基于戊二酰亚胺骨架的含硫化合物及其应用 [433]
82. 局部组合物及用途 [432]
83. 靶向EGFR蛋白降解剂及其在非小细胞肺癌中的应用 [431]
84. HETEROCYCLE AND GLUTARIMIDE SKELETON-BASED COMPOUND AND APPLICATIO.. [431]
85. 靶向B7-H3抗体-MMAE偶联物及其应用 [428]
86. Accurate Retention Time Prediction Based on Monolinked Peptide Inf.. [425]
87. TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEI.. [425]
88. Discovery of a first-in-class protein degrader for the c-ros oncog.. [420]
89. 免疫调节化合物及其抗肿瘤应用 [418]
90. 免疫调节化合物及其抗肿瘤应用 [414]
91. 局部组合物及用途 [412]
92. COMPOSITION AND USE OF CAS PROTEIN INHIBITORS [411]
93. 基于杂环和戊二酰亚胺骨架的化合物及其应用 [410]
94. 免疫调节化合物及其抗肿瘤应用 [410]
95. COMPOSITION AND USE OF CAS PROTEIN INHIBITORS [409]
96. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase.. [409]
97. 基于杂环和戊二酰亚胺骨架的化合物及其应用 [403]
98. 基于BCL-2家族蛋白配体化合物开发的蛋白降解剂及它们的应用 [403]
99. Heterocycle and glutarimide skeleton-based compound and applicatio.. [401]
100. EGFR蛋白降解剂及其抗肿瘤应用 [399]

下载量

1. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiti.. [722]
2. Zika virus infects renal proximal tubular epithelial cells with pr.. [422]
3. Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prod.. [354]
4. Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRA.. [347]
5. KPT330 improves Cas9 precision genome- and base-editing by selecti.. [346]
6. Structural plasticity of green fluorescent protein to amino acid d.. [305]
7. The PROTAC selectively degrading Bcl-x(L) represents a novel Hedge.. [196]
8. Structure-based discovery of dual pathway inhibitors for SARS-CoV-.. [192]
9. Precision Genome and Base Editing by Regulating mRNA Nuclear Expor.. [87]
10. N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugat.. [33]
11. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Usin.. [21]
12. Combretastatin A4-derived payloads for antibody-drug conjugates [19]
13. Bis(vinylsulfonyl)piperazines as efficient linkers for highly homo.. [18]
14. Decision tree searching strategy to boost the identification of cr.. [18]
15. Structure-based discovery of SIAIS001 as an oral bioavailability A.. [17]
16. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Met.. [17]
17. Exploiting synthetic lethality in PDAC with antibody drug conjugat.. [17]
18. Two novel strategies to overcome the resistance to ALK tyrosine ki.. [16]
19. Development of a MMAE-based antibody-drug conjugate targeting B7-H.. [16]
20. Effective degradation of EGFR(L858R+T790M) mutant proteins by CRBN.. [14]
21. Divinylsulfonamides enable the construction of homogeneous antibod.. [12]
22. Chemical reagents for the enrichment of modified peptides in MS-ba.. [12]
23. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug .. [11]
24. A novel mass spectrometry-cleavable, phosphate-based enrichable an.. [11]
25. Discovery and characterization of novel potent BCR-ABL degraders b.. [11]
26. Selective lysine modification of native peptides via aza-Michael a.. [10]
27. H2O-Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reaction.. [10]
28. Construction of an IMiD-based azide library as a kit for PROTAC re.. [10]
29. Discovery of a first-in-class protein degrader for the c-ros oncog.. [10]
30. Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bon.. [9]
31. Novel strategies to target EGFR proteins for degradation and their.. [9]
32. 靶向EGFR蛋白降解剂及其在非小细胞肺癌中的应用 [9]
33. EGFR蛋白降解剂及其抗肿瘤应用 [9]
34. An electron transfer path connects subunits of a mycobacterial res.. [8]
35. 基于戊二酰亚胺骨架的化合物及其应用 [7]
36. Reactive oxygen species-responsive Pre-PROTAC for tumor-specific p.. [7]
37. EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF [7]
38. Phenyldivinylsulfonamides for the construction of antibody–drug c.. [7]
39. Applications of macrocyclic molecules in cancer therapy: Target ca.. [7]
40. Targeting Bcl-xL is a potential therapeutic strategy for extranoda.. [7]
41. Development of the nonreceptor tyrosine kinase FER-targeting PROTA.. [7]
42. EGFR蛋白降解剂及其抗肿瘤应用 [6]
43. Protein degradation targeting compound, anti-tumor application, .. [5]
44. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase.. [5]
45. 基于杂环和戊二酰亚胺骨架的化合物及其应用 [5]
46. Site-specific construction of triptolide-based antibody-drug conju.. [5]
47. Utilization of macrocyclic peptides to target protein-protein inte.. [5]
48. ALK蛋白调节剂及其抗肿瘤应用 [5]
49. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase.. [5]
50. ALK蛋白降解剂及其在癌症治疗中的用途 [5]
51. In situ tailored confining microenvironment for lung cancer sphero.. [5]
52. 一种氘代喜树碱衍生物及其制备方法与用途 [5]
53. N-Phenyl-N-aceto-vinylsulfonamides as Efficient and Chemoselective.. [4]
54. Photoactivatable Fluorogenic Labeling via Turn-On "Click-Like" Nit.. [4]
55. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase [4]
56. METHOD FOR PREPARING LENALIDOMIDE DERIVATIVES [4]
57. 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用 [4]
58. ALK蛋白降解剂及其抗肿瘤应用 [4]
59. The target proteolytic compounds, its anti-tumor applications, i.. [4]
60. The proteolytic agent for use in the therapy of cancer and ALK [4]
61. A mild phenoxysilyl linker for self-immolative release of antibody.. [4]
62. ALK蛋白降解剂及其抗肿瘤应用 [4]
63. 一种包括Nafamostat和K777的药物组合及其应用 [4]
64. Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity a.. [4]
65. Accessible Method for the Development of Novel Sterol Analogues wi.. [3]
66. Tris(2-carboxyethyl)phosphine promotes hydrolysis of iminoboronate.. [3]
67. AXL promotes Zika virus infection in astrocytes by antagonizing ty.. [3]
68. ALK protein degradation agent and anti-tumor application thereof [3]
69. 鬼臼毒素在激活BMP信号通路中的用途 [3]
70. A functional SNP rs895819 on pre-miR-27a is associated with bipola.. [3]
71. ALK蛋白调节剂及其抗肿瘤应用 [3]
72. 基于NAMPT靶蛋白的蛋白降解复合物及其应用 [3]
73. 靶蛋白降解化合物及其抗肿瘤用途，中间体和中间体 [3]
74. 靶向B7-H3抗体-MMAE偶联物及其应用 [3]
75. Fine-tuning phenoxy silyl scaffolds for the development of glutath.. [3]
76. A facile and efficient transposon mutagenesis method for generatio.. [2]
77. Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Contr.. [2]
78. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Ki.. [2]
79. Development of a Brigatinib degrader (SIAIS117) as a potential tre.. [2]
80. PROTEIN DEGRADING AGENT AND USE THEREOF IN TREATMENT OF DISEASES [2]
81. ER PROTEIN REGULATOR AND APPLICATION THEREOF [2]
82. ALK PROTEIN DEGRADERS AND THEIR USE IN CANCER THERAPY [2]
83. Accurate Retention Time Prediction Based on Monolinked Peptide Inf.. [2]
84. ER蛋白调节剂及其用途 [2]
85. TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEI.. [2]
86. ALK proteolytic agents and their use in cancer therapy [2]
87. EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF [2]
88. 基于NAMPT靶蛋白的蛋白降解化合物及其应用 [2]
89. ALK蛋白调节剂及其抗肿瘤应用 [2]
90. ALK蛋白调节剂及其抗肿瘤应用 [2]
91. Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, disp.. [2]
92. Identification of a diverse synthetic abietane diterpenoid library.. [1]
93. Antibody-Drug Conjugates [1]
94. A Concise Formal Synthesis of (-)-Hamigeran B [1]
95. LLDT-288, a novel triptolide analogue exhibits potent antitumor ac.. [1]
96. Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived pept.. [1]
97. FUNCTIONALITY INDEPENDENT LABELING OF ORGANIC COMPOUNDS [1]
98. 一种双乙烯磺酰胺连接子及其制备和应用 [1]
99. 一种非对称转座子及其应用 [1]
100. ALK PROTEIN DEGRADATION AGENT AND ANTI-TUMOR APPLICATION THEREOF [1]