ShanghaiTech University Knowledge Management System
| A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors | |
| 2022-02 | |
| 发表期刊 | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| EISSN | 1745-7254 |
| 发表状态 | 已发表 |
| DOI | 10.1038/s41401-021-00668-7 |
| 摘要 | The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no effective treatment. In this study, we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors, which simultaneously act on the host ribosome, viral RNA as well as RNA-dependent RNA polymerases, and nucleocapsid protein of the virus, to impair viral translation, frameshifting, replication, and assembly. Driven by this strategy, three alkaloids, including lycorine, emetine, and cephaeline, were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels potently. The findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs. |
| 关键词 | SARS-CoV-2 inhibitors RdRp host ribosome Virus RNA |
| URL | 查看原文 |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000644822100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 原始文献类型 | Article; Early Access |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126683 |
| 专题 | 生命科学与技术学院_博士生 免疫化学研究所 免疫化学研究所_特聘教授组_蒋华良组 生命科学与技术学院_硕士生 信息科学与技术学院_硕士生 免疫化学研究所_PI研究组_白芳组 |
| 共同第一作者 | Shang, Wei-juan; Yin, Wan-chao; Ge, Huan; Wang, Lin |
| 通讯作者 | Zhu, Li-li; Zhang, Lei-ke; Bai, Fang |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 5.East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China; 6.Imperial Coll London, Dept Chem, London, England; 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 生命科学与技术学院; 免疫化学研究所 |
| 通讯作者单位 | 生命科学与技术学院; 免疫化学研究所 |
| 第一作者的第一单位 | 生命科学与技术学院 |
| 推荐引用方式 GB/T 7714 | Ren, Peng-xuan,Shang, Wei-juan,Yin, Wan-chao,et al. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors[J]. ACTA PHARMACOLOGICA SINICA,2022. |
| APA | Ren, Peng-xuan.,Shang, Wei-juan.,Yin, Wan-chao.,Ge, Huan.,Wang, Lin.,...&Bai, Fang.(2022).A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors.ACTA PHARMACOLOGICA SINICA. |
| MLA | Ren, Peng-xuan,et al."A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors".ACTA PHARMACOLOGICA SINICA (2022). |
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