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Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy 期刊论文
ADVANCED SCIENCE, 2024
作者:  Yao Hu;  Hao Yang;  Mingwei Li;  Zhicheng Zhong;  Yongqi Zhou
Adobe PDF(6212Kb)  |  收藏  |  浏览/下载:112/2  |  提交时间:2024/09/11
DiffPROTACs is a deep learning-based generator for proteolysis targeting chimeras 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 5
作者:  Li, Fenglei;  Hu, Qiaoyu;  Zhou, Yongqi;  Yang, Hao;  Bai, Fang
Adobe PDF(1631Kb)  |  收藏  |  浏览/下载:178/35  |  提交时间:2024/08/26
Conformational Space Profiling Enhances Generic Molecular Representation for AI-Powered Ligand-Based Drug Discovery 期刊论文
ADVANCED SCIENCE, 2024
作者:  Wang, Lin;  Wang, Shihang;  Yang, Hao;  Li, Shiwei;  Wang, Xinyu
Adobe PDF(4769Kb)  |  收藏  |  浏览/下载:121/8  |  提交时间:2024/09/08
CIB2 as a Ca2+ Sensor for Auditory Mechano-Electrical Transduction and Linked to Genetic-Heterogeneity of TMC1 in Hearing Loss 预印本
2024
作者:  Wu, Shaoxuan;  Lin, Lin;  Hu, Qiaoyu;  Yao, Xuebo;  Wang, Hongyang
Adobe PDF(1958Kb)  |  收藏  |  浏览/下载:97/0  |  提交时间:2024/08/14
Structural basis of antagonist selectivity in endothelin receptors 期刊论文
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1
作者:  Hou, Junyi;  Liu, Shenhui;  Zhang, Xiaodan;  Tu, Guowei;  Wu, Lijie
Adobe PDF(4532Kb)  |  收藏  |  浏览/下载:131/7  |  提交时间:2024/08/14
Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase 期刊论文
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1
作者:  Qiao, Hang;  Wang, Zilu;  Yang, Hao;  Xia, Mingyu;  Yang, Guang
Adobe PDF(3569Kb)  |  收藏  |  浏览/下载:103/10  |  提交时间:2024/08/14
Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 29
作者:  Novelli, Flavia;  Yoshikawa, Yoshie;  Vitto, Veronica Angela Maria;  Modesti, Lorenzo;  Minaai, Michael
Adobe PDF(5723Kb)  |  收藏  |  浏览/下载:91/1  |  提交时间:2024/08/14
Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1
作者:  Wang, Dongdong;  Li, Yanxia;  Yang, Hao;  Shen, Xiaoqi;  Shi, Xiaolin
Adobe PDF(3220Kb)  |  收藏  |  浏览/下载:197/43  |  提交时间:2024/07/02
Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies 期刊论文
JACS AU, 2024, 卷号: 4, 期号: 4, 页码: 1632-1645
作者:  Chao Xu;  Xianglei Zhang;  Lianghao Zhao;  Gennady M. Verkhivker;  Fang Bai
Adobe PDF(6628Kb)  |  收藏  |  浏览/下载:75/3  |  提交时间:2024/09/24
五环三萜衍生物的医药用途、五环三萜衍生物、包含其的药物组合物 专利
申请号:CN202311207625.0,申请日期: 2024-03-22,类型:发明申请,状态:公开
发明人:  梅良和;  谢成英;  白芳;  王亚芳;  徐岚松
Adobe PDF(8828Kb)  |  收藏  |  浏览/下载:219/0  |  提交时间:2024/03/22