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一种噻唑烷二酮类化合物、其药物组合物和其用途 专利
申请号:CN202410806451.8,申请日期: 2024-12-24,类型:发明申请,状态:公开
发明人:  范国平;  白芳;  许红涛;  祝献民;  王林
Adobe PDF(2056Kb)  |  收藏  |  浏览/下载:18/1  |  提交时间:2024/12/24
MAI-TargetFisher: A proteome-wide drug target prediction method synergetically enhanced by artificial intelligence and physical modeling 期刊论文
ACTA PHARMACOLOGICA SINICA, 2024
作者:  Li, Shiwei;  Ren, Pengxuan;  Wang, Lin;  Han, Qilei;  Li, Fenglei
收藏  |  浏览/下载:69/0  |  提交时间:2024/12/02
Motif-guided Identification of KRAS-interacting Proteins 期刊论文
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1
作者:  Sanan, Wu;  Xiaoyang,Gao;  Di, Wu;  Lu, Liu;  Han, Yao
Adobe PDF(5705Kb)  |  收藏  |  浏览/下载:117/16  |  提交时间:2024/12/02
Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy 期刊论文
ADVANCED SCIENCE, 2024
作者:  Yao Hu;  Hao Yang;  Mingwei Li;  Zhicheng Zhong;  Yongqi Zhou
Adobe PDF(6212Kb)  |  收藏  |  浏览/下载:198/5  |  提交时间:2024/09/11
DiffPROTACs is a deep learning-based generator for proteolysis targeting chimeras 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 5
作者:  Li, Fenglei;  Hu, Qiaoyu;  Zhou, Yongqi;  Yang, Hao;  Bai, Fang
Adobe PDF(1631Kb)  |  收藏  |  浏览/下载:298/49  |  提交时间:2024/08/26
Conformational Space Profiling Enhances Generic Molecular Representation for AI-Powered Ligand-Based Drug Discovery 期刊论文
ADVANCED SCIENCE, 2024, 卷号: 11, 期号: 40
作者:  Wang, Lin;  Wang, Shihang;  Yang, Hao;  Li, Shiwei;  Wang, Xinyu
Adobe PDF(4769Kb)  |  收藏  |  浏览/下载:224/16  |  提交时间:2024/09/08
CIB2 as a Ca2+ Sensor for Auditory Mechano-Electrical Transduction and Linked to Genetic-Heterogeneity of TMC1 in Hearing Loss 预印本
2024
作者:  Wu, Shaoxuan;  Lin, Lin;  Hu, Qiaoyu;  Yao, Xuebo;  Wang, Hongyang
Adobe PDF(1958Kb)  |  收藏  |  浏览/下载:167/0  |  提交时间:2024/08/14
Structural basis of antagonist selectivity in endothelin receptors 期刊论文
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1
作者:  Hou, Junyi;  Liu, Shenhui;  Zhang, Xiaodan;  Tu, Guowei;  Wu, Lijie
Adobe PDF(4532Kb)  |  收藏  |  浏览/下载:214/9  |  提交时间:2024/08/14
Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase 期刊论文
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1
作者:  Qiao, Hang;  Wang, Zilu;  Yang, Hao;  Xia, Mingyu;  Yang, Guang
Adobe PDF(3569Kb)  |  收藏  |  浏览/下载:162/11  |  提交时间:2024/08/14
Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 29
作者:  Novelli, Flavia;  Yoshikawa, Yoshie;  Vitto, Veronica Angela Maria;  Modesti, Lorenzo;  Minaai, Michael
Adobe PDF(5723Kb)  |  收藏  |  浏览/下载:158/1  |  提交时间:2024/08/14