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SOS1蛋白降解剂及其应用 专利
申请号:CN202310427933.8,申请日期: 2024-10-22,类型:发明申请,状态:实质审查
发明人:  谢成英;  姜标;  杨小宝
Adobe PDF(5367Kb)  |  收藏  |  浏览/下载:45/0  |  提交时间:2024/10/22
Discovery of Novel BCL6-Targeting PROTACs with Effective Antitumor Activities against DLBCL in Vitro and in Vivo 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277
作者:  Dazhao Mi;  Cheng Li(李成);  Yuzhan Li;  Mingyue Yao;  Yan Li
Adobe PDF(7740Kb)  |  收藏  |  浏览/下载:104/9  |  提交时间:2024/09/02
五环三萜衍生物的医药用途、五环三萜衍生物、包含其的药物组合物 专利
申请号:CN202311207625.0,申请日期: 2024-03-22,类型:发明申请,状态:公开
发明人:  梅良和;  谢成英;  白芳;  王亚芳;  徐岚松
Adobe PDF(8828Kb)  |  收藏  |  浏览/下载:219/0  |  提交时间:2024/03/22
Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers 期刊论文
ADVANCED SCIENCE, 2024
作者:  Wang, Yafang;  Xu, Lansong;  Ling, Lijun;  Yao, Mingyue;  Shi, Shangxuan
Adobe PDF(9804Kb)  |  收藏  |  浏览/下载:75/2  |  提交时间:2024/09/20
Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling 期刊论文
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023
作者:  Yafang Wang;  Mingyue Yao;  Cheng Li (李成);  Kexin Yang;  Xiaolong Qin
Adobe PDF(16153Kb)  |  收藏  |  浏览/下载:101/5  |  提交时间:2024/09/02
Structural basis of peptide recognition and activation of endothelin receptors 期刊论文
NATURE COMMUNICATIONS;, 2023, 卷号: 14, 期号: 1
作者:  Ji, Yujie;  Duan, Jia;  Yuan, Qingning;  He, Xinheng;  Yang, Gong
Adobe PDF(2001Kb)  |  收藏  |  浏览/下载:791/196  |  提交时间:2023/03/24
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor 期刊论文
NATURE COMMUNICATIONS;, 2023, 卷号: 14, 期号: 1
作者:  Duan, Jia;  Xu, Peiyu;  Zhang, Huibing;  Luan, Xiaodong;  Yang, Jiaqi
Adobe PDF(3025Kb)  |  收藏  |  浏览/下载:748/156  |  提交时间:2023/03/24
三唑酰胺类化合物及其制备方法和用途 专利
申请号:WOCN23084136,申请日期: 2023-10-05,类型:发明申请,状态:未进入国家阶段-PCT有效期内
发明人:  Cheng Jianjun;  Xie Chengying;  Yan Wenzhong;  Yang Kexin
Unknown(7251Kb)  |  收藏  |  浏览/下载:189/0  |  提交时间:2023/10/06
三唑酰胺类化合物及其制备方法和用途 专利
申请号:CN202211494346.2,申请日期: 2023-09-29,类型:发明申请,状态:公开
发明人:  程建军;  谢成英;  蒋华良;  闫文仲
Adobe PDF(5474Kb)  |  收藏  |  浏览/下载:290/0  |  提交时间:2023/09/29
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257
作者:  Mei, Lianghe;  Xu, Lansong;  Wu, Sanan;  Wang, Yafang;  Xu, Chao
Adobe PDF(11458Kb)  |  收藏  |  浏览/下载:352/4  |  提交时间:2023/07/11