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Structural insights into ligand recognition and activation of human purinergic receptor P2Y14 期刊论文
CELL DISCOVERY, 2025, 卷号: 11, 期号: 1
作者:  Gu, Quanchang;  Lv, Zhenyu;  Wang, Tianxin;  Tang, Wenqin
Adobe PDF(4552Kb)  |  收藏  |  浏览/下载:0/0  |  提交时间:2025/05/26
Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness 期刊论文
NEURON, 2025
作者:  Simeng Zhao;  Qiuxiang Yang;  Zehua Yu;  Cenfeng Chu;  Shengqi Dai
Adobe PDF(9318Kb)  |  收藏  |  浏览/下载:39/8  |  提交时间:2025/05/12
靶向FZD7的单克隆抗体及其制备方法和用途 专利
申请号:US18470595,申请日期: 2025-03-20,类型:发明申请,状态:公开
发明人:  Fei Xu;  Lu Xu;  Tingting Wu
Adobe PDF(1075Kb)  |  收藏  |  浏览/下载:76/1  |  提交时间:2025/03/21
The structural basis of the G protein–coupled receptor and ion channel axis 期刊论文
CURRENT RESEARCH IN STRUCTURAL BIOLOGY, 2025
作者:  Luo YL(罗煜林);  Sun LP(孙立萍);  Peng Y(彭瑶)
Adobe PDF(2148Kb)  |  收藏  |  浏览/下载:59/8  |  提交时间:2025/04/04
Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss-Newton Method 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2025
作者:  Yoshikado, Takashi;  Aoki, Yasunori;  Nakamura, Ryo;  Shida, Saeko;  Sugiyama, Yuichi
Adobe PDF(1329Kb)  |  收藏  |  浏览/下载:95/3  |  提交时间:2025/02/17
The immune checkpoint molecule B7-H4 regulates R-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling 期刊论文
MOLECULAR METABOLISM, 2025, 卷号: 91
作者:  Xia, Fangzhen;  Zhang, Ziteng;  Qian, Zhen;  Fang, Xiaoyu;  Wang, Junxue
Adobe PDF(4609Kb)  |  收藏  |  浏览/下载:282/4  |  提交时间:2024/12/17
一种自动化细胞表达重组蛋白的设备 专利
申请号:CN202411396224.9,申请日期: 2024-12-31,类型:发明申请,状态:实质审查
发明人:  
Adobe PDF(947Kb)  |  收藏  |  浏览/下载:292/8  |  提交时间:2024/12/31
Cryo-EM structure of Nipah virus RNA polymerase complex 期刊论文
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 50
作者:  Yiru Wang;  Lixia Zhao;  Yi Zhang;  Yuhan Wang;  Jiao Tang
Adobe PDF(1099Kb)  |  收藏  |  浏览/下载:342/2  |  提交时间:2024/11/27
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharmacokinetic parameters? 期刊论文
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 12
作者:  Tsuchitani, Toshiaki;  Kato, Motohiro;  Tomaru, Atsuko;  Aoki, Yasunori;  Sugiyama, Yuichi
Adobe PDF(6271Kb)  |  收藏  |  浏览/下载:278/2  |  提交时间:2024/12/17
Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1
作者:  Zinzula, Luca;  Beck, Florian;  Camasta, Marianna;  Bohn, Stefan;  Liu, Chuan
Adobe PDF(3911Kb)  |  收藏  |  浏览/下载:282/2  |  提交时间:2024/12/17
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