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Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method 期刊论文
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 10
作者:  Nakamura, Ryo;  Yoshikado, Takashi;  Aoki, Yasunori;  Sugiyama, Yuichi;  Chiba, Koji
Adobe PDF(4911Kb)  |  收藏  |  浏览/下载:19/2  |  提交时间:2024/11/04
Structure basis of ligand recognition and activation of GPR55 期刊论文
CELL RESEARCH, 2024
作者:  Chang, Hao;  Li, Xiaoting;  Shen, Ling;  Ge, Xuanrui;  Hao, Shuming
Adobe PDF(1392Kb)  |  收藏  |  浏览/下载:7/1  |  提交时间:2024/11/11
昙花提取物在调控皮肤节律相关通路中的应用 专利
申请号:CN202310307578.0,申请日期: 2024-09-27,类型:发明申请,状态:实质审查
发明人:  彭瑶;  谈绮文;  刘志杰;  周方方
Adobe PDF(1212Kb)  |  收藏  |  浏览/下载:132/3  |  提交时间:2024/09/27
褪黑素在调控CRY1和PER2基因表达中的应用 专利
申请号:CN202310310232.6,申请日期: 2024-09-27,类型:发明申请,状态:实质审查
发明人:  彭瑶;  谈绮文;  刘志杰;  汪玲
Adobe PDF(1174Kb)  |  收藏  |  浏览/下载:115/2  |  提交时间:2024/09/27
昙花提取物及其在调控多巴胺受体通路中的应用 专利
申请号:CN202310317332.1,申请日期: 2024-09-27,类型:发明申请,状态:公开
发明人:  彭瑶;  谈绮文;  刘志杰;  胡霁;  李菲
Adobe PDF(667Kb)  |  收藏  |  浏览/下载:112/1  |  提交时间:2024/09/27
Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93Amouse G93A mouse model of amyotrophic lateral sclerosis 期刊论文
CELL REPORTS, 2024, 卷号: 43, 期号: 9
作者:  Liu, Zihao;  Zhang, Huan;  Lu, Kaili;  Chen, Li;  Zhang, Yueqi
Adobe PDF(8796Kb)  |  收藏  |  浏览/下载:78/1  |  提交时间:2024/09/18
Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives 期刊论文
FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15
作者:  Fan, Mengjie;  Fan, Xiaoyao;  Lai, Yangfan;  Chen, Jin;  Peng, Yifan
Adobe PDF(3518Kb)  |  收藏  |  浏览/下载:62/1  |  提交时间:2024/10/14
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Aoki, Yasunori;  Rowland, Malcom;  Sugiyama, Yuichi
Adobe PDF(1837Kb)  |  收藏  |  浏览/下载:91/2  |  提交时间:2024/08/26
Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Weiss, H. Markus;  Sugiyama, Yuichi;  van Duijn, Esther
Adobe PDF(515Kb)  |  收藏  |  浏览/下载:86/1  |  提交时间:2024/08/14
Bayesian Occam's Razor to Optimize Models for Complex Systems 预印本
2024
作者:  Wang, Chenxi;  Zhao, Jihui;  Zheng, Jingjing;  Raveh, Barak;  He, Xuming
Adobe PDF(23197Kb)  |  收藏  |  浏览/下载:157/25  |  提交时间:2024/06/24