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GPCR large-amplitude dynamics by F-19-NMR of aprepitant bound to the neurokinin 1 receptor
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 15
Authors:
Pan, Benxun
;
Liu, Dongsheng
;
Yang, Lingyun
;
Wuthrich, Kurt
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View/Download:2/0
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Submit date:2022/05/18
aromatic ring flips
NMR saturation transfer
nanodiscs
protein dynamics
2D [F-19,F- 19]-EXSY
GPCR large-amplitude dynamics by 19F-NMR of aprepitant bound to the neurokinin 1 receptor
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 15
Authors:
Pan, Benxun
;
Liu, Dongsheng
;
Yang, Lingyun
;
Wüthrich, Kurt
Adobe PDF(1505Kb)
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View/Download:8/1
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Submit date:2022/05/17
aromatic ring flips
NMR saturation transfer
nanodiscs
protein dynamics
2D [19F,19F]-EXSY
G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling
期刊论文
MOLECULES, 2022, 卷号: 27, 期号: 9
Authors:
Ge, Haoyi
;
Wang, Huixia
;
Pan, Benxun
;
Feng, Dandan
;
Guo, Canyong
Adobe PDF(2948Kb)
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View/Download:4/0
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Submit date:2022/05/17
G protein-coupled receptors
19F-NMR
membrane mimetics
stable-isotope labeling
in-membrane chemical modification
amino-acid-specific NMR labeling
equence-specific NMR labeling
Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for F-19-NMR studies in solution
期刊论文
FEBS JOURNAL, 2021, 卷号: 288, 期号: 13, 页码: 4053-4063
Authors:
Wang, Huixia
;
Hu, Wanhui
;
Liu, Dongsheng
;
Wuthrich, Kurt
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View/Download:195/0
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Submit date:2021/02/19
F-19-NMR
glucagon receptor
glucagon-like peptide-1 receptor
GPCR
negative allosteric modulator
Crystal structure of semisynthetic obelin-v
期刊论文
PROTEIN SCIENCE, 2021
Authors:
Larionova, Marina D.
;
Wu, Lijie
;
Eremeeva, Elena, V
;
Natashin, Pavel, V
;
Gulnov, Dmitry, V
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View/Download:46/0
  |  
Submit date:2021/12/03
analog
bioluminescence
coelenterazine
coelenterazine-v
obelin
photoprotein
protein structure
A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 卷号: 143, 期号: 40, 页码: 16320-16325
Authors:
Wang, Xiaoyan
;
Liu, Dongsheng
;
Shen, Ling
;
Li, Fahui
;
Li, Yongze
Adobe PDF(2179Kb)
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View/Download:63/0
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Submit date:2021/11/19
Lipid metabolism and oxidative stress in HPV-related cancers
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2021, 卷号: 172, 页码: 226-236
Authors:
Cruz-Gregorio, Alfredo
;
Aranda-Rivera, Ana Karina
;
Ortega-Lozano, Ariadna Jazmin
;
Pedraza-Chaverri, Jose
;
Mendoza-Hoffmann, Francisco
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View/Download:32/0
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Submit date:2021/08/27
Lipid metabolism
Cellular trafficking
beta-oxidation
Lipogenesis
Epithelial-mesenchymal transition (EMT)
Reactive oxygen species (ROS)
Ferroptosis autophagy
Apoptosis
Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists
期刊论文
PHARMACEUTICALS, 2020, 卷号: 13, 期号: 9
Authors:
Zhang, Jinfeng
;
Yan, Wenzhong
;
Duan, Wenwen
;
Wuthrich, Kurt
;
Cheng, Jianjun
Adobe PDF(2336Kb)
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View/Download:197/49
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Submit date:2020/11/24
GPCR
immuno-oncology
Parkinson's disease
drug binding modes
cancer therapy
Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists
期刊论文
MICROSCALE THERMOPHYSICAL ENGINEERING, 2020, 卷号: 13, 期号: 237
Authors:
Zhang JF(张金凤)
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View/Download:122/0
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Submit date:2020/11/04
A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET
期刊论文
CHEMICAL COMMUNICATIONS, 2020, 卷号: 56, 期号: 51, 页码: 6941-6944
Authors:
Shi, Pan
;
Zhang, Yanan
;
Lv, Pei
;
Fang, Wei
;
Ling, Shenglong
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View/Download:95/0
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Submit date:2020/07/10