Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole
Liu, Dazhi1; Wei, Yifeng2; Liu, Xuyang3,4; Zhou, Yan1; Jiang, Li1; Yin, Jinyu1; Wang, Feifei1; Hu, Yiling1; Urs, Ankanahalli N. Nanjaraj1; Liu, Yanhong5; Ang, Ee Lui2; Zhao, Suwen3,4; Zhao, Huimin2,6; Zhang, Yan1
2018-10-11
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume9
Status已发表
DOI10.1038/s41467-018-06627-x
AbstractSkatole is a malodorous compound that contributes to the characteristic smell of animal faeces. Although skatole has long been known to originate from bacterial tryptophan fermentation, the enzyme catalysing its formation has so far remained elusive. Here we report the use of comparative genomics for the discovery of indoleacetate decarboxylase, an O-2-sensitive glycyl radical enzyme catalysing the decarboxylation of indoleacetate to form skatole as the terminal step of tryptophan fermentation in certain anaerobic bacteria. We describe its biochemical characterization and compare it to other glycyl radical decarboxylases. Indoleacetate decarboxylase may serve as a genetic marker for the identification of skatole-producing environmental and human-associated bacteria, with impacts on human health and the livestock industry.
Indexed BySCI
Language英语
Funding ProjectNational Science Foundation of China[31570060]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000447075700012
PublisherNATURE PUBLISHING GROUP
WOS KeywordIII RIBONUCLEOTIDE-REDUCTASE ; AROMATIC-AMINO-ACIDS ; P-CRESOL ; 4-HYDROXYPHENYLACETATE DECARBOXYLASE ; ACTIVATING ENZYME ; SP NOV. ; 3-METHYLINDOLE ; PROTEIN ; MECHANISMS ; PNEUMOTOXICITY
Original Document TypeArticle
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28116
Collection生命科学与技术学院_博士生
iHuman研究所_PI研究组_赵素文组
Corresponding AuthorZhao, Suwen; Zhao, Huimin; Zhang, Yan
Affiliation1.Tianjin Univ, Sch Pharmaceut Sci & Technol, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
2.ASTAR, Inst Chem & Engn Sci, Metab Engn Res Lab, Singapore 138669, Singapore
3.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201202, Peoples R China
5.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
6.Univ Illinois, Dept Chem & Biomol Engn, 600 South Mathews Ave, Urbana, IL 61801 USA
Corresponding Author AffilicationiHuman Institute;  School of Life Science and Technology
Recommended Citation
GB/T 7714
Liu, Dazhi,Wei, Yifeng,Liu, Xuyang,et al. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole[J]. NATURE COMMUNICATIONS,2018,9.
APA Liu, Dazhi.,Wei, Yifeng.,Liu, Xuyang.,Zhou, Yan.,Jiang, Li.,...&Zhang, Yan.(2018).Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.NATURE COMMUNICATIONS,9.
MLA Liu, Dazhi,et al."Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole".NATURE COMMUNICATIONS 9(2018).
Files in This Item: Download All
File Name/Size DocType Version Access License
10.1038@s41467-018-0(1130KB)期刊论文出版稿开放获取CC BYView Download
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Liu, Dazhi]'s Articles
[Wei, Yifeng]'s Articles
[Liu, Xuyang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Dazhi]'s Articles
[Wei, Yifeng]'s Articles
[Liu, Xuyang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Dazhi]'s Articles
[Wei, Yifeng]'s Articles
[Liu, Xuyang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.1038@s41467-018-06627-x.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.