Aerobic glycolysis imaging of epileptic foci during the inter-ictal period

doi:10.1016/j.ebiom.2022.104004

	Aerobic glycolysis imaging of epileptic foci during the inter-ictal period
	Zhang, Miao 1; Qin, Qikai2,3,4 ; Zhang, Shuning2,3,4 ; Liu, Wei 5; Meng, Hongping 1; Xu, Mengyang2,3,4,6 ; Huang, Xinyun 1; Lin, Xiaozhu 1; Lin, Mu 7; Herman, Peter 8,9,10; Hyder, Fahmeed 8,9,10,11; Stevens, Raymond C.2,3 ; Wang, Zheng 12,13,14,15; Li, Biao 1,16; Thompson, Garth J.2
	2022-05
发表期刊	EBIOMEDICINE (IF:9.7[JCR-2023],9.2[5-Year])
ISSN	2352-3964
卷号	79
发表状态	已发表
DOI	10.1016/j.ebiom.2022.104004
摘要	["Background In drug-resistant epilepsy, surgical resection of the epileptic focus can end seizures. However, success is dependent on the ability to identify foci locations and, unfortunately, current methods like electrophysiology and positron emission tomography can give contradictory results. During seizures, glucose is metabolized at epileptic foci through aerobic glycolysis, which can be imaged through the oxygen-glucose index (OGI) biomarker. However, inter-ictal (between seizures) OGI changes have not been studied, which has limited its application.","Methods 18 healthy controls and 24 inter-ictal, temporal lobe epilepsy patients underwent simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) scans. We used [F-18]fluorodeoxyglucose-PET (FDG-PET) to detect cerebral glucose metabolism, and calibrated functional MRI to acquire relative oxygen consumption. With these data, we calculated relative OGI maps.","Findings While bilaterally symmetrical in healthy controls, we observed, in patients during the inter-ictal period, higher OGI ipsilateral to the epileptic focus than contralateral. While traditional FDG-PET results and temporal lobe OGI results usually both agreed with invasive electrophysiology, in cases where FDG-PET disagreed with electrophysiology, temporal lobe OGI agreed with electrophysiology, and vice-versa.","Interpretation As either our novel epilepsy biomarker or traditional approaches located foci in every case, our work provides promising insights into metabolic changes in epilepsy. Our method allows single-session OGI measurement which can be useful in other diseases.","Funding This work was supported by ShanghaiTech University, the Shanghai Municipal Government, the National Natural Science Foundation of China Grant (No. 81950410637) and Shanghai Municipal Key Clinical Specialty (No. shslczdzk03403). F. H. and P. H. were supported by USA National Institute of Health grants (R01 NS-100106, R01 MH-067528).Z. W. was supported by the Key-Area Research and Development Program of Guangdong Province 2019B030335001), National Natural Science Foundation of China (No. 82151303), and National Key R&D Program of China (No. 2021ZD0204002). Copyright (C) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)"]
关键词	Oxygen-glucose index Epilepsy Inter-ictal Calibrated fMRI Lactate Biomarker
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China["82151303","81950410637"] ; Shanghai Municipal Key Clinical Specialty[shslczdzk03403] ; USA National Institute of Health["R01 NS-100106","R01 MH-067528"] ; Key-Area Research and Development Program of Guangdong Province[2019B030335001] ; National Key R&D Program of China[2021ZD0204002]
WOS研究方向	General & Internal Medicine ; Research & Experimental Medicine
WOS类目	Medicine, General & Internal ; Medicine, Research & Experimental
WOS记录号	WOS:000821811900024
出版者	ELSEVIER
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/176149
专题	生命科学与技术学院_硕士生 iHuman研究所_特聘教授组_Raymond Stevens组 iHuman研究所_PI研究组_Garth John Thompson组生命科学与技术学院_博士生
通讯作者	Li, Biao; Thompson, Garth J.
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Nucl Med, Sch Med, Shanghai 200025, Peoples R China 2.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurosurg, Sch Med, Shanghai 200025, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 7.Siemens Healthineers Ltd, MR Collaborat, Shanghai 201318, Peoples R China 8.Yale Univ, Magnet Resonance Res Ctr MRRC, New Haven, CT 06520 USA 9.Yale Univ, Quantitat Neurosci Magnet Resonance QNMR Core Ctr, New Haven, CT 06520 USA 10.Yale Univ, Radiol & Biomed Imaging, New Haven, CT 06520 USA 11.Yale Univ, Biomed Engn, New Haven, CT 06520 USA 12.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China 13.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China 14.Peking Univ, IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China 15.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 16.Ruijin Ctr, Collaborat Innovat Ctr Mol Imaging Precis Med, Shanghai 200025, Peoples R China
通讯作者单位	iHuman研究所
推荐引用方式 GB/T 7714	Zhang, Miao,Qin, Qikai,Zhang, Shuning,et al. Aerobic glycolysis imaging of epileptic foci during the inter-ictal period[J]. EBIOMEDICINE,2022,79.
APA	Zhang, Miao.,Qin, Qikai.,Zhang, Shuning.,Liu, Wei.,Meng, Hongping.,...&Thompson, Garth J..(2022).Aerobic glycolysis imaging of epileptic foci during the inter-ictal period.EBIOMEDICINE,79.
MLA	Zhang, Miao,et al."Aerobic glycolysis imaging of epileptic foci during the inter-ictal period".EBIOMEDICINE 79(2022).