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Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method 期刊论文
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 10
作者:  Nakamura, Ryo;  Yoshikado, Takashi;  Aoki, Yasunori;  Sugiyama, Yuichi;  Chiba, Koji
Adobe PDF(4911Kb)  |  收藏  |  浏览/下载：19/2  |  提交时间：2024/11/04
Structure basis of ligand recognition and activation of GPR55 期刊论文
CELL RESEARCH, 2024
作者:  Chang, Hao;  Li, Xiaoting;  Shen, Ling;  Ge, Xuanrui;  Hao, Shuming
Adobe PDF(1392Kb)  |  收藏  |  浏览/下载：7/1  |  提交时间：2024/11/11
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Aoki, Yasunori;  Rowland, Malcom;  Sugiyama, Yuichi
Adobe PDF(1837Kb)  |  收藏  |  浏览/下载：91/2  |  提交时间：2024/08/26
Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Weiss, H. Markus;  Sugiyama, Yuichi;  van Duijn, Esther
Adobe PDF(515Kb)  |  收藏  |  浏览/下载：86/1  |  提交时间：2024/08/14
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2024
作者:  Tsuchitani, Toshiaki;  Tomaru, Atsuko;  Aoki, Yasunori;  Ishiguro, Naoki;  Tsuda, Yasuhiro
Adobe PDF(4173Kb)  |  收藏  |  浏览/下载：129/1  |  提交时间：2024/05/27
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2023
作者:  Aoki, Yasunori;  Sugiyama, Yuichi
Adobe PDF(3274Kb)  |  收藏  |  浏览/下载：191/0  |  提交时间：2023/11/27
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept 期刊论文
DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 9
作者:  Sugiyama, Yuichi;  Aoki, Yasunori
Adobe PDF(1799Kb)  |  收藏  |  浏览/下载：197/41  |  提交时间：2023/11/27