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Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium) 期刊论文
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2025
作者:  Asano, Satoshi;  Galetin, Aleksandra;  Tomita, Yoshiko;  Giacomini, Kathleen M.;  Chu, Xiaoyan
Adobe PDF(3586Kb)  |  收藏  |  浏览/下载：6/0  |  提交时间：2025/06/04
Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss-Newton Method 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2025, 卷号: 14, 期号: 4, 页码: 770-780
作者:  Yoshikado, Takashi;  Aoki, Yasunori;  Nakamura, Ryo;  Shida, Saeko;  Sugiyama, Yuichi
Adobe PDF(1329Kb)  |  收藏  |  浏览/下载：100/3  |  提交时间：2025/02/17
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharmacokinetic parameters? 期刊论文
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 12
作者:  Tsuchitani, Toshiaki;  Kato, Motohiro;  Tomaru, Atsuko;  Aoki, Yasunori;  Sugiyama, Yuichi
Adobe PDF(6271Kb)  |  收藏  |  浏览/下载：291/2  |  提交时间：2024/12/17
Structure basis of ligand recognition and activation of GPR55 期刊论文
CELL RESEARCH, 2024
作者:  Chang, Hao;  Li, Xiaoting;  Shen, Ling;  Ge, Xuanrui;  Hao, Shuming
Adobe PDF(1392Kb)  |  收藏  |  浏览/下载：379/21  |  提交时间：2024/11/11
Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method 期刊论文
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 10
作者:  Nakamura, Ryo;  Yoshikado, Takashi;  Aoki, Yasunori;  Sugiyama, Yuichi;  Chiba, Koji
Adobe PDF(4911Kb)  |  收藏  |  浏览/下载：331/4  |  提交时间：2024/11/04
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Aoki, Yasunori;  Rowland, Malcom;  Sugiyama, Yuichi
Adobe PDF(1837Kb)  |  收藏  |  浏览/下载：391/2  |  提交时间：2024/08/26
Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15
作者:  Weiss, H. Markus;  Sugiyama, Yuichi;  van Duijn, Esther
Adobe PDF(515Kb)  |  收藏  |  浏览/下载：387/1  |  提交时间：2024/08/14
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2024, 卷号: 13, 期号: 7, 页码: 1224-1237
作者:  Tsuchitani, Toshiaki;  Tomaru, Atsuko;  Aoki, Yasunori;  Ishiguro, Naoki;  Tsuda, Yasuhiro
Adobe PDF(4173Kb)  |  收藏  |  浏览/下载：325/1  |  提交时间：2024/05/27
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2023
作者:  Aoki, Yasunori;  Sugiyama, Yuichi
Adobe PDF(3274Kb)  |  收藏  |  浏览/下载：400/0  |  提交时间：2023/11/27
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept 期刊论文
DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 9
作者:  Sugiyama, Yuichi;  Aoki, Yasunori
Adobe PDF(1799Kb)  |  收藏  |  浏览/下载：477/131  |  提交时间：2023/11/27
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