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Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2024
作者:  Tsuchitani, Toshiaki;  Tomaru, Atsuko;  Aoki, Yasunori;  Ishiguro, Naoki;  Tsuda, Yasuhiro
Adobe PDF(4173Kb)  |  收藏  |  浏览/下载：34/0  |  提交时间：2024/05/27
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models 期刊论文
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2023
作者:  Aoki, Yasunori;  Sugiyama, Yuichi
Adobe PDF(3274Kb)  |  收藏  |  浏览/下载：125/0  |  提交时间：2023/11/27
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept 期刊论文
DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 9
作者:  Sugiyama, Yuichi;  Aoki, Yasunori
Adobe PDF(1799Kb)  |  收藏  |  浏览/下载：116/25  |  提交时间：2023/11/27