Ligands of Adrenergic Receptors: A Structural Point of View

doi:10.3390/biom11070936

	Ligands of Adrenergic Receptors: A Structural Point of View
	Wu, Yiran1 ; Zeng, Liting1,2 ; Zhao, Suwen1,2
	2021-07
发表期刊	BIOMOLECULES (IF:4.8[JCR-2023],5.4[5-Year])
EISSN	2218-273X
卷号	11 期号:7
DOI	10.3390/biom11070936
摘要	Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.
关键词	adrenergic receptor adrenoreceptor aminergic receptor GPCR activation mechanism receptor-ligand interactions selectivity allosteric modulator structure-based drug design
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收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000676834300001
出版者	MDPI
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127864
专题	iHuman研究所_PI研究组_赵素文组生命科学与技术学院生命科学与技术学院_博士生
通讯作者	Zhao, Suwen
作者单位	1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	iHuman研究所
通讯作者单位	iHuman研究所; 生命科学与技术学院
第一作者的第一单位	iHuman研究所
推荐引用方式 GB/T 7714	Wu, Yiran,Zeng, Liting,Zhao, Suwen. Ligands of Adrenergic Receptors: A Structural Point of View[J]. BIOMOLECULES,2021,11(7).
APA	Wu, Yiran,Zeng, Liting,&Zhao, Suwen.(2021).Ligands of Adrenergic Receptors: A Structural Point of View.BIOMOLECULES,11(7).
MLA	Wu, Yiran,et al."Ligands of Adrenergic Receptors: A Structural Point of View".BIOMOLECULES 11.7(2021).