ShanghaiTech University Knowledge Management System
| Ligands of Adrenergic Receptors: A Structural Point of View | |
| 2021-07 | |
| Source Publication | BIOMOLECULES
 |
| EISSN | 2218-273X |
| Volume | 11Issue:7 |
| DOI | 10.3390/biom11070936 |
| Abstract | Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors. |
| Keyword | adrenergic receptor adrenoreceptor aminergic receptor GPCR activation mechanism receptor-ligand interactions selectivity allosteric modulator structure-based drug design |
| URL | 查看原文 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000676834300001 |
| Publisher | MDPI |
| Original Document Type | Review |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127864 |
| Collection | iHuman研究所_PI研究组_赵素文组 生命科学与技术学院 生命科学与技术学院_博士生 |
| Corresponding Author | Zhao, Suwen |
| Affiliation | 1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| First Author Affilication | iHuman Institute |
| Corresponding Author Affilication | iHuman Institute; School of Life Science and Technology |
| First Signature Affilication | iHuman Institute |
| Recommended Citation GB/T 7714 | Wu, Yiran,Zeng, Liting,Zhao, Suwen. Ligands of Adrenergic Receptors: A Structural Point of View[J]. BIOMOLECULES,2021,11(7). |
| APA | Wu, Yiran,Zeng, Liting,&Zhao, Suwen.(2021).Ligands of Adrenergic Receptors: A Structural Point of View.BIOMOLECULES,11(7). |
| MLA | Wu, Yiran,et al."Ligands of Adrenergic Receptors: A Structural Point of View".BIOMOLECULES 11.7(2021). |
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