Ligands of Adrenergic Receptors: A Structural Point of View
2021-07
Source PublicationBIOMOLECULES
EISSN2218-273X
Volume11Issue:7
DOI10.3390/biom11070936
AbstractAdrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.
Keywordadrenergic receptor adrenoreceptor aminergic receptor GPCR activation mechanism receptor-ligand interactions selectivity allosteric modulator structure-based drug design
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Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000676834300001
PublisherMDPI
Original Document TypeReview
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Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127864
CollectioniHuman研究所_PI研究组_赵素文组
生命科学与技术学院
生命科学与技术学院_博士生
Corresponding AuthorZhao, Suwen
Affiliation
1.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China;
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
First Author AffilicationiHuman Institute
Corresponding Author AffilicationiHuman Institute;  School of Life Science and Technology
First Signature AffilicationiHuman Institute
Recommended Citation
GB/T 7714
Wu, Yiran,Zeng, Liting,Zhao, Suwen. Ligands of Adrenergic Receptors: A Structural Point of View[J]. BIOMOLECULES,2021,11(7).
APA Wu, Yiran,Zeng, Liting,&Zhao, Suwen.(2021).Ligands of Adrenergic Receptors: A Structural Point of View.BIOMOLECULES,11(7).
MLA Wu, Yiran,et al."Ligands of Adrenergic Receptors: A Structural Point of View".BIOMOLECULES 11.7(2021).
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