上海科技大学知识管理系统

本发明涉及生物领域，特别是涉及一种简易高效的肿瘤免疫治疗生物标志物及其用途。本发明提供一种存储有计算机程序的计算机可读存储介质，所述计算机程序被执行时可以实现方法步骤，所述方法步骤包括：获取样本的抗原呈递基因mRNA的表达数据和内参基因mRNA的表达数据；根据式I计算获得肿瘤抗原呈递指数TAPS＝Average[(Log2APMexp)–Average(Log2REFexp)](式I)。本发明所提供的肿瘤免疫治疗生物标志物能够高效区分对免疫治疗有效和对免疫治疗无效的病人。

The invention relates to the biological field, and particularly to a simple and efficient tumor immunotherapy biomarker and use thereof. The invention provides a computer-readable storage medium in which a computer program is stored. The computer program can realize method steps in execution. The method steps comprise acquiring expression data of an antigen presentation gene mRNA of a sample and expression data of a reference gene mRNA; and acquiring a tumor antigen presentation index according to a formula I, namely TAPS=Average[(Log2APMexp)-Average(Log2REFexp)]. The tumor immunotherapy biomarker according to the invention can efficiently differentiate the patient to whom immunotherapy is effective and the patient to whom immunotherapy is ineffective.