Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells

doi:10.1177/0963689720920825

	Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells
	Wang, Zhixiong 1,2,3; Zhou, Guomin 1; Risu, Na 3; Fu, Jiayu 3; Zou, Yan4 ; Tang, Jiaxing4 ; Li, Long4 ; Liu, Hui 1; Liu, Qian 1; Zhu, Xuekai4
	2020-01
发表期刊	CELL TRANSPLANTATION (IF:3.2[JCR-2023],4.1[5-Year])
ISSN	0963-6897
EISSN	1555-3892
卷号	29 页码:#VALUE!
DOI	10.1177/0963689720920825
摘要	Chimeric antigen receptor (CAR) T-cell immunotherapy still faces many challenges in the treatment of solid tumors, one of which is T-cell dysfunction or exhaustion. Immunomodulator lenalidomide may improve CAR T-cell function. In this study, the effects of lenalidomide on CAR T-cell functions (cytotoxicity, cytokine secretion, and cell proliferation) were investigated. Two different CAR T cells (CD133-specific CAR and HER2-specific CAR) were prepared, and the corresponding target cells including human glioma cell line U251 CD133-OE that overexpress CD133 and human breast cancer cell line MDA-MB-453 were used for functional assay. We found that lenalidomide promoted the killing of U251 CD133-OE by CD133-CAR T cells, the cytokine secretion, and the proliferation of CD133-CAR T cells. Lenalidomide also enhanced the cytotoxicity against MDA-MB-453 and the cytokine secretion of HER2-CAR T cells but did not affect their proliferation significantly. Furthermore, lenalidomide may regulate the function of CAR T cells by inducing the degradation of transcription factors Ikaros and Aiolos.
关键词	chimeric antigen receptor lenalidomide immunotherapy CD133 HER2
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Cell Biology ; Research & Experimental Medicine ; Transplantation
WOS类目	Cell & Tissue Engineering ; Medicine, Research & Experimental ; Transplantation
WOS记录号	WOS:000606584100037
出版者	SAGE PUBLICATIONS INC
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126000
专题	免疫化学研究所_PI研究组_刘佳组免疫化学研究所_PI研究组_朱学锴组 T细胞工程实验室免疫化学研究所_特聘教授组_蒋华良组生命科学与技术学院_博士生
通讯作者	Zhu, Xuekai
作者单位	1.Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai, Peoples R China; 2.Maanshan Univ, Maanshan, Peoples R China; 3.Osaka Univ, Grad Sch Med, Div Hlth Sci, Osaka, Japan; 4.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Wang, Zhixiong,Zhou, Guomin,Risu, Na,et al. Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells[J]. CELL TRANSPLANTATION,2020,29:#VALUE!.
APA	Wang, Zhixiong.,Zhou, Guomin.,Risu, Na.,Fu, Jiayu.,Zou, Yan.,...&Zhu, Xuekai.(2020).Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells.CELL TRANSPLANTATION,29,#VALUE!.
MLA	Wang, Zhixiong,et al."Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells".CELL TRANSPLANTATION 29(2020):#VALUE!.