Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists

doi:10.3390/ph13090237

	Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists
	Zhang, Jinfeng1,2 ; Yan, Wenzhong1 ; Duan, Wenwen1 ; Wuthrich, Kurt1,3 ; Cheng, Jianjun1
	2020-09
发表期刊	PHARMACEUTICALS (IF:4.3[JCR-2023],4.6[5-Year])
卷号	13 期号:9
发表状态	已发表
DOI	10.3390/ph13090237
摘要	The A(2A) adenosine receptor (A(2A) AR) plays critical roles in human physiology and pathophysiology, which makes it an important drug target. Previous drug-discovery efforts targeting the A(2A) AR have been focused on the use of A(2A) AR antagonists for the treatment of Parkinson's disease. More recently, the A(2A) AR has attracted additional attention for its roles in immuno-oncology, and a number of A(2A) AR antagonists are currently used as lead compounds for antitumor drugs in both preclinical models and clinical trials. This review surveys recent advances in the development of A(2A) AR antagonists for cancer immunotherapy. The therapeutic potential of representative A(2A) AR antagonists is discussed based on both animal efficacy studies and clinical data.
关键词	GPCR immuno-oncology Parkinson's disease drug binding modes cancer therapy
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000580369900001
出版者	MDPI
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123939
专题	生命科学与技术学院_硕士生 iHuman研究所_特聘教授组_Kurt Wuthrich组 iHuman研究所_公共科研平台_IT平台 iHuman研究所_PI研究组_程建军组
通讯作者	Cheng, Jianjun
作者单位	1.ShanghaiTech Univ, IHuman Inst, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Scripps Res, Dept Integrated Struct & Computat Biol, La Jolla, CA 92037 USA
第一作者单位	iHuman研究所; 生命科学与技术学院
通讯作者单位	iHuman研究所
第一作者的第一单位	iHuman研究所
推荐引用方式 GB/T 7714	Zhang, Jinfeng,Yan, Wenzhong,Duan, Wenwen,et al. Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists[J]. PHARMACEUTICALS,2020,13(9).
APA	Zhang, Jinfeng,Yan, Wenzhong,Duan, Wenwen,Wuthrich, Kurt,&Cheng, Jianjun.(2020).Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists.PHARMACEUTICALS,13(9).
MLA	Zhang, Jinfeng,et al."Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists".PHARMACEUTICALS 13.9(2020).