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Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24
作者:
Muya Xiong
;
Tianqing Nie
;
Zhewen Li
;
Meiyi Hu
;
Haixia Su
Adobe PDF(7488Kb)
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浏览/下载:265/5
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提交时间:2024/12/02
Binding energy
Molecular docking
Structural dynamics
Coronaviruses
Covalent reaction
Dynamics simulation
Expert knowledge
Hybrid QM/MM
Inhibition mechanisms
Multi-scale simulation
Pathogenics
Reaction mechanism
Structure based drug designs
Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
期刊论文
ADVANCED SCIENCE, 2023, 卷号: 11, 期号: 9
作者:
Zhang, Yanjun
;
Sun, Jing
;
Zheng, Jian
;
Li, Suxiang
;
Rao, Haiyue
Adobe PDF(10205Kb)
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浏览/下载:278/2
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提交时间:2024/01/05
Diseases
Health risks
Mammals
MERS
Nanoparticles
Vaccines
Animal model
Broad spectrum
Coronaviruses
Global public health
Immunogenicity
Mosaic RBD nanoparticle vaccine coronavirus
Protective efficacy
Protective immunities
Receptor-binding domains
Wild-type strain
Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2022
作者:
Ling, Zhiyang
;
Yi, Chunyan
;
Sun, Xiaoyu
;
Yang, Zhuo
;
Sun, Bing
Adobe PDF(3355Kb)
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浏览/下载:711/247
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提交时间:2022/12/19
antibody therapy
broad neutralizing antibody
human coronaviruses
SARS-CoV-2
Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation
期刊论文
ADVANCED BIOLOGY, 2022
作者:
Gao, Junjie
;
Mei, Hong
;
Sun, Jing
;
Li, Hao
;
Huang, Yuege
Adobe PDF(3617Kb)
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浏览/下载:442/0
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提交时间:2022/03/04
Bone
Diseases
Metabolism
Viruses
Bone marrow
Bone marrow-derived macrophage
Coronaviruses
Host cells
Medical complications
Neuropilin-1
Neuropilins
Osteoclast differentiation
Severe acute respiratory syndrome coronavirus
Severe acute respiratory syndrome coronavirus 2
The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals
期刊论文
VIRUSES-BASEL, 2022, 卷号: 14, 期号: 3
作者:
Wang, Fenghua
;
Chen, Cheng
;
Wang, Zefang
;
Han, Xu
;
Shi, Peidian
Adobe PDF(3770Kb)
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浏览/下载:1337/468
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提交时间:2022/04/20
coronaviruses
porcine deltacoronavirus
main protease
broad-spectrum antivirals
COVIDSum: A linguistically enriched SciBERT-based summarization model for COVID-19 scientific papers
期刊论文
JOURNAL OF BIOMEDICAL INFORMATICS, 2022, 卷号: 127
作者:
Cai, Xiaoyan
;
Liu, Sen
;
Yang, Libin
;
Lu, Yan
;
Zhao, Jintao
Adobe PDF(1781Kb)
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浏览/下载:545/0
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提交时间:2022/02/13
Abstracting
Coronavirus
Diagnosis
Disease control
Linguistics
Signal encoding
Abstractive summarization
Co-occurrence Graph
Coronaviruses
COVID-19 scientific paper
Language model
Linguistically enriched pre-trained language model
SciBERT
Scientific papers
Summarization models
Word co-occurrence
Daydream: A healing game for mitigating quarantine-induced negative emotions with music adventure
会议论文
CHI PLAY 2020 - EXTENDED ABSTRACTS OF THE 2020 ANNUAL SYMPOSIUM ON COMPUTER-HUMAN INTERACTION IN PLAY, Virtual, Online, Canada, November 2, 2020 - November 4, 2020
作者:
Ji, Chen
;
Nishino, Hiroki
Adobe PDF(4829Kb)
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浏览/下载:166/0
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提交时间:2022/12/09
Coronavirus
Music
Serious games
Coronaviruses
Design concept
Game design
Interactive music
Making experience
Mental health
Research topics
Stress-induced
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