Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models

doi:10.1002/advs.202303366

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	Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
	Zhang, Yanjun 1; Sun, Jing 1; Zheng, Jian 2; Li, Suxiang 1; Rao, Haiyue 1; Dai, Jun 3; Zhang, Zhaoyong 1; Wang, Yanqun 1; Liu, Donglan 1; Chen, Zhao 1; Ran, Wei 1; Zhu, Airu 1; Li, Fang 1; Yan, Qihong 1; Wang, Yiliang 1; Yu, Kuai 1; Zhang, Shengnan 1; Wang, Dong 1; Tang, Yanhong 1; Liu, Banghui 4; Cheng, Linling 1; Huo, Jiandong 1,5; Perlman, Stanley 2; Zhao, Jingxian 1,5; Zhao, Jincun1,5,6,7,8
	2023
发表期刊	ADVANCED SCIENCE (IF:14.3[JCR-2023],16.3[5-Year])
ISSN	2198-3844
EISSN	2198-3844
卷号	11 期号:9
发表状态	已发表
DOI	10.1002/advs.202303366
摘要	To combat SARS-CoV-2 variants and MERS-CoV, as well as the potential re-emergence of SARS-CoV and spillovers of sarbecoviruses, which pose a significant threat to global public health, vaccines that can confer broad-spectrum protection against betacoronaviruses (β-CoVs) are urgently needed. A mosaic ferritin nanoparticle vaccine is developed that co-displays the spike receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 Wild-type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10 µg administered at a 21-day interval induced a Th1-biased immune response in mice and elicited robust cross-reactive neutralizing antibody responses against a variety of β-CoVs, including a series of SARS-CoV-2 variants. It is also able to effectively protect against challenges of SARS-CoV, MERS-CoV, and SARS-CoV-2 variants in not only young mice but also the more vulnerable mice through induction of long-lived immunity. Together, these results suggest that this mosaic 3-RBD nanoparticle has the potential to be developed as a pan-β-CoV vaccine. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
关键词	Diseases Health risks Mammals MERS Nanoparticles Vaccines Animal model Broad spectrum Coronaviruses Global public health Immunogenicity Mosaic RBD nanoparticle vaccine coronavirus Protective efficacy Protective immunities Receptor-binding domains Wild-type strain
收录类别	EI
语种	英语
出版者	John Wiley and Sons Inc
EI入藏号	20235115246916
EI主题词	Coronavirus
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.7 Health Care ; 761 Nanotechnology ; 933 Solid State Physics
原始文献类型	Article in Press
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/347976
专题	免疫化学研究所免疫化学研究所_特聘教授组_赵金存组
通讯作者	Huo, Jiandong; Perlman, Stanley; Zhao, Jingxian; Zhao, Jincun
作者单位	1.State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou; 510300, China; 2.Department of Microbiology and Immunology, University of Iowa, Iowa City; IA; 52242, United States; 3.Guangzhou Customs District Technology Center, Guangzhou; 510700, China; 4.State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou; 510530, China; 5.Guangzhou laboratory, Bio-island, Guangzhou; 510320, China; 6.Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou; 510060, China; 7.Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, the Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen; 518112, China; 8.Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai; 201210, China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Zhang, Yanjun,Sun, Jing,Zheng, Jian,et al. Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models[J]. ADVANCED SCIENCE,2023,11(9).
APA	Zhang, Yanjun.,Sun, Jing.,Zheng, Jian.,Li, Suxiang.,Rao, Haiyue.,...&Zhao, Jincun.(2023).Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models.ADVANCED SCIENCE,11(9).
MLA	Zhang, Yanjun,et al."Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models".ADVANCED SCIENCE 11.9(2023).