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合作作者[TOP 5]

  • 赵素文

    合作成果数：18

  • 吴屹然

    合作成果数：16

  • 合作成果数：12

  • 陶厚朝

    合作成果数：9

  • Raymond C. Stevens

    合作成果数：8

访问统计


  总访问量
 4102
  访问来源
    内部： 30
    外部： 4072
    国内： 3730
    国外： 372

  年访问量
 302
  访问来源
    内部： 0
    外部： 302
    国内： 287
    国外： 15

  月访问量
 130
  访问来源
    内部： 0
    外部： 130
    国内： 122
    国外： 8

访问量

访问量

1. A structurally guided dissection-then-evolution strategy for ligan.. [3202]
2. Crystal structure of a multi-domain human smoothened receptor in c.. [1623]
3. Cryo-EM structures of orphan GPR21 signaling complexes [1560]
4. Cryo-EM structure of constitutively active human Frizzled 7 in com.. [1263]
5. The activation mechanism and antibody binding mode for orphan GPR2.. [1173]
6. Crystal structure of the Frizzled 4 receptor in a ligand-free stat.. [1109]
7. Determination of an underneath binding in the transmembrane domain.. [1055]
8. Colocalization Strategy Unveils an Underside Binding Site in the T.. [1052]
9. Multiregional profiling of the brain transmembrane proteome uncove.. [875]
10. The structure-based traceless specific fluorescence labeling of th.. [829]
11. Structural Basis for Apelin Control of the Human Apelin Receptor [827]
12. Elucidation of Distinct Modular Assemblies of Smoothened Receptor .. [824]
13. Structural basis of ligand recognition and self-activation of orph.. [739]
14. Structural insight into apelin receptor-G protein stoichiometry [738]
15. 一种卷曲受体7的小分子抑制剂及其制备方法和应用 [626]
16. Structure-Activity Relationship Studies of Hydantoin-Cored Ligands.. [625]
17. The importance of ligands for G protein-coupled receptor stability [615]
18. Structure-Based Ligand Discovery Targeting the Transmembrane Domai.. [614]
19. 一种FZD7鼠源单克隆抗体及其制备方法和应用 [582]
20. Toward the first orphan GPCR structure [567]
21. Cryo-EM structure of human kappa-opioid receptor-G(i) complex boun.. [543]
22. 平滑受体配体及其应用 [542]
23. Structural and Druggability Landscape of Frizzled G Protein-Couple.. [538]
24. Structural insights into the lipid and ligand regulation of a huma.. [506]
25. 孤儿受体GPR52晶体结构揭示配体结合新机制 [504]
26. Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therap.. [486]
27. The versatile binding landscape of the TAAR1 pocket for LSD and ot.. [459]
28. Molecular recognition of the atypical chemokine-like peptide GPR15.. [455]
29. Structural Mass Spectrometry Captures Residue-Resolved Comprehensi.. [416]
30. The binding mechanism of an anti-multiple myeloma antibody to the .. [403]
31. A framework for Frizzled-G protein coupling and implications to th.. [401]
32. Structural basis of Frizzled 4 in recognition of Dishevelled 2 unv.. [387]
33. Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Ty.. [374]
34. Nonlinear relationship between body mass index and serum uric acid.. [369]
35. Association between glycemia risk index and arterial stiffness in .. [353]
36. Crystal structure of the first orphan GPCR [307]
37. 人源Apelin受体与天然配体Apelin的多肽类似物的复合物晶体结构 [306]
38. Unveiling the structural mechanisms of nonpeptide ligand recognit.. [288]
39. 强啡肽单抗融合蛋白的克隆、表达及功能分析 [287]
40. Structural insights into the regulation of monomeric and dimeric a.. [161]
41. Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan R.. [58]
42. 靶向FZD7的单克隆抗体及其制备方法和用途 [19]

下载量

1. A structurally guided dissection-then-evolution strategy for ligan.. [648]
2. Crystal structure of a multi-domain human smoothened receptor in c.. [398]
3. Cryo-EM structure of constitutively active human Frizzled 7 in com.. [377]
4. Cryo-EM structures of orphan GPR21 signaling complexes [350]
5. The activation mechanism and antibody binding mode for orphan GPR2.. [246]
6. Molecular recognition of the atypical chemokine-like peptide GPR15.. [66]
7. The binding mechanism of an anti-multiple myeloma antibody to the .. [52]
8. Structural basis of Frizzled 4 in recognition of Dishevelled 2 unv.. [41]
9. The versatile binding landscape of the TAAR1 pocket for LSD and ot.. [26]
10. Multiregional profiling of the brain transmembrane proteome uncove.. [25]
11. Structure-Based Ligand Discovery Targeting the Transmembrane Domai.. [18]
12. Determination of an underneath binding in the transmembrane domain.. [17]
13. Colocalization Strategy Unveils an Underside Binding Site in the T.. [16]
14. Unveiling the structural mechanisms of nonpeptide ligand recognit.. [14]
15. The structure-based traceless specific fluorescence labeling of th.. [13]
16. Crystal structure of the Frizzled 4 receptor in a ligand-free stat.. [11]
17. Structural Mass Spectrometry Captures Residue-Resolved Comprehensi.. [11]
18. Structural insights into the regulation of monomeric and dimeric a.. [10]
19. Toward the first orphan GPCR structure [9]
20. The importance of ligands for G protein-coupled receptor stability [8]
21. 平滑受体配体及其应用 [8]
22. A framework for Frizzled-G protein coupling and implications to th.. [8]
23. Structural Basis for Apelin Control of the Human Apelin Receptor [6]
24. Structure-Activity Relationship Studies of Hydantoin-Cored Ligands.. [5]
25. 一种卷曲受体7的小分子抑制剂及其制备方法和应用 [5]
26. Structural insight into apelin receptor-G protein stoichiometry [4]
27. Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Ty.. [4]
28. Structural and Druggability Landscape of Frizzled G Protein-Couple.. [3]
29. Elucidation of Distinct Modular Assemblies of Smoothened Receptor .. [3]
30. Structural insights into the lipid and ligand regulation of a huma.. [3]
31. Association between glycemia risk index and arterial stiffness in .. [3]
32. Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therap.. [2]
33. Structural basis of ligand recognition and self-activation of orph.. [2]
34. Nonlinear relationship between body mass index and serum uric acid.. [2]
35. 孤儿受体GPR52晶体结构揭示配体结合新机制 [1]
36. 人源Apelin受体与天然配体Apelin的多肽类似物的复合物晶体结构 [1]