Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target

doi:10.1016/j.celrep.2018.10.015

	Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target
	Zhao, Huan 1,2; Tian, Xueying 3; He, Lingjuan 1,2; Li, Yan 1,2; Pu, Wenjuan 1,2; Liu, Qiaozhen 1,2; Tang, Juan 1,2; Wu, Jiaying 1; Cheng, Xin 1; Liu, Yang 4; Zhou, Qingtong5 ; Tan, Zhen 6; Bai, Fan 4; Xu, Fei5,7 ; Smart, Nicola 8; Zhou, Bin1,2,3,7
	2018-10-30
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	25 期号:5 页码:1241-+
发表状态	已发表
DOI	10.1016/j.celrep.2018.10.015
摘要	Identification of cellular surface markers that distinguish tumorous from normal vasculature is important for the development of tumor vessel-targeted therapy. Here, we show that Apj, a G protein-coupled receptor, is highly enriched in tumor endothelial cells but absent from most endothelial cells of adult tissues in homeostasis. By genetic targeting using Apj-CreER and Apj-DTRGFP-Luciferase, we demonstrated that hypoxia-VEGF signaling drives expansion of Apj(+) tumor vessels and that targeting of these vessels, genetically and pharmacologically, remarkably inhibits tumor angiogenesis and restricts tumor growth. These in vivo findings implicate Apj(+) vessels as a key driver of pathological angiogenesis and identify Apj(+) endothelial cells as an important therapeutic target for the anti-angiogenic treatment of tumors.
收录类别	SCI ; SCIE
语种	英语
资助项目	Royal Society-Newton Advanced Fellowship[NA170109]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000448675900013
出版者	CELL PRESS
WOS关键词	PROTEIN-COUPLED RECEPTOR ; IN-VIVO ; APELIN-APJ ; ENDOTHELIAL-CELLS ; ANGIOGENIC FACTOR ; GENETIC ABLATION ; TRANSGENIC MICE ; TOXIN GENE ; T-CELLS ; EXPRESSION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28295
专题	iHuman研究所_PI研究组_赵素文组 iHuman研究所_特聘教授组_Andrej Sali组生命科学与技术学院_特聘教授组_周斌组 iHuman研究所_PI研究组_徐菲组
通讯作者	Zhou, Bin
作者单位	1.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Chinese Acad Sci, Shanghai 200031, Peoples R China 3.Jinan Univ, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Guangdong, Peoples R China 4.Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China 5.ShanghaiTech Univ, IHuman Inst, Shanghai 201210, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Dept Pediat Hematol Oncol, Xinhua Hosp, Shanghai 200092, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 8.Univ Oxford, British Heart Fdn Ctr Regenerat Med, Dept Physiol Anat & Genet, Oxford, England
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhao, Huan,Tian, Xueying,He, Lingjuan,et al. Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target[J]. CELL REPORTS,2018,25(5):1241-+.
APA	Zhao, Huan.,Tian, Xueying.,He, Lingjuan.,Li, Yan.,Pu, Wenjuan.,...&Zhou, Bin.(2018).Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target.CELL REPORTS,25(5),1241-+.
MLA	Zhao, Huan,et al."Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target".CELL REPORTS 25.5(2018):1241-+.