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| Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders | |
Xu, Liang1,2  ; Carrer, Andrea3,4; Zonta, Francesco1,3; Qu, Zhihu1; Ma, Peixiang1; Li, Sheng1; Ceriani, Federico3,4,11; Buratto, Damiano3,4; Crispino, Giulia3,4,5; Zorzi, Veronica3,6; Ziraldo, Gaia3,4,6; Bruno, Francesca4,5; Nardin, Chiara3,7; Peres, Chiara3; Mazzarda, Flavia3,7; Salvatore, Anna M.3; Raspa, Marcello3; Scavizzi, Ferdinando3; Chu, Youjun1; Xie, Sichun1; Yang, Xuemei8; Liao, Jun8; Liu, Xiao1,2,9; Wang, Wei1; Wang, Shanshan1; Yang, Guang1; Lerner, Richard A.10; Mammano, Fabio1,3,4,5; Xu, Liang12,13; Carrer, Andrea14,15; Zonta, Francesco12,14; Qu, Zhihu12; Ma, Peixiang12; Li, Sheng12; Ceriani, Federico14,15,22; Buratto, Damiano14,15; Crispino, Giulia14,15,16; Zorzi, Veronica14,17; Ziraldo, Gaia14,15,17; Bruno, Francesca15,16; Nardin, Chiara14,18; Peres, Chiara14; Mazzarda, Flavia14,18; Salvatore, Anna M.14; Raspa, Marcello14; Scavizzi, Ferdinando14; Chu, Youjun12; Xie, Sichun12; Yang, Xuemei19; Liao, Jun19; Liu, Xiao12,13,20; Wang, Wei12; Wang, Shanshan12; Yang, Guang12; Lerner, Richard A.21; Mammano, Fabio12,14,15,16
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| 2017-09-22 | |
| 发表期刊 | FRONTIERS IN MOLECULAR NEUROSCIENCE
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| ISSN | 1662-5099 |
| 卷号 | 10 |
| 发表状态 | 已发表 |
| DOI | 10.3389/fnmol.2017.00298 |
| 摘要 | Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases. Eight of these result from variants of connexin 26 (Cx26), a protein critically involved in cell-cell signaling in the inner ear and skin. Lack of non-toxic drugs with defined mechanisms of action poses a serious obstacle to therapeutic interventions for diseases caused by mutant connexins. In particular, molecules that specifically modulate connexin hemichannel function without affecting gap junction channels are considered of primary importance for the study of connexin hemichannel role in physiological as well as pathological conditions. Monoclonal antibodies developed in the last three decades have become the most important class of therapeutic biologicals. Recombinant methods permit rapid selection and improvement of monoclonal antibodies from libraries with large diversity. |
| 关键词 | syndromic autosomal hereditary deafness cochlea keratinocytes connexins antibody library antibody structure epitope identification |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | NSFC[31500632] |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000411723100001 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS关键词 | GAP-JUNCTION CHANNELS ; ATP RELEASE ; EPIDERMOLYSIS-BULLOSA ; MURINE MODEL ; PROTEIN ; PERMEABILITY ; LIBRARIES ; DISEASE ; SINGLE ; PURIFICATION |
| 原始文献类型 | Article |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/9920 |
| 专题 | 生命科学与技术学院_特聘教授组_James E. Rothman组 生命科学与技术学院 生命科学与技术学院_PI研究组_廖军组 免疫化学研究所 免疫化学研究所_特聘教授组_结构生物化学实验室 免疫化学研究所_特聘教授组_功能筛选实验室 免疫化学研究所_公共科研平台_信息平台 免疫化学研究所_公共科研平台_影像平台 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 免疫化学研究所_公共科研平台_高通量筛选平台 免疫化学研究所_公共科研平台_生物医学大数据平台 |
| 通讯作者 | Mammano, Fabio; Mammano, Fabio |
| 作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China 3.CNR Inst Cell Biol & Neurobiol, Monterotondo, Italy 4.Univ Padua, Dept Phys & Astron G Galilei, Padua, Italy 5.Venetian Inst Mol Med, Padua, Italy 6.Catholic Univ, Sch Med, Inst Otolaryngol, Rome, Italy 7.Roma Tre Univ, Dept Sci, Rome, Italy 8.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 9.Univ Chinese Acad Sci, Beijing, Peoples R China 10.Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA 11.Univ Sheffield, Dept Biomed Sci, Sheffield, S Yorkshire, England 12.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 13.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China 14.CNR Inst Cell Biol & Neurobiol, Monterotondo, Italy 15.Univ Padua, Dept Phys & Astron G Galilei, Padua, Italy 16.Venetian Inst Mol Med, Padua, Italy 17.Catholic Univ, Sch Med, Inst Otolaryngol, Rome, Italy 18.Roma Tre Univ, Dept Sci, Rome, Italy 19.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 20.Univ Chinese Acad Sci, Beijing, Peoples R China 21.Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA 22.Univ Sheffield, Dept Biomed Sci, Sheffield, S Yorkshire, England |
| 第一作者单位 | 免疫化学研究所 |
| 通讯作者单位 | 免疫化学研究所 |
| 第一作者的第一单位 | 免疫化学研究所 |
| 推荐引用方式 GB/T 7714 | Xu, Liang,Carrer, Andrea,Zonta, Francesco,et al. Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2017,10. |
| APA | Xu, Liang.,Carrer, Andrea.,Zonta, Francesco.,Qu, Zhihu.,Ma, Peixiang.,...&Mammano, Fabio.(2017).Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders.FRONTIERS IN MOLECULAR NEUROSCIENCE,10. |
| MLA | Xu, Liang,et al."Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders".FRONTIERS IN MOLECULAR NEUROSCIENCE 10(2017). |
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