Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice
2019-08-28
发表期刊NUTRITION & METABOLISM (IF:3.9[JCR-2023],4.3[5-Year])
ISSN1743-7075
卷号16期号:1
发表状态已发表
DOI10.1186/s12986-019-0388-x
摘要

Background Calorie restriction (CR) has been well proved to be a powerful tool to improve metabolic health associated with aging; and many types of CR have been proposed. Intermittent CR has become a trend in recent years due to its better compliance than continuous CR every day. However, there are few studies that directly compare the interventional activity of intermittent CR vs continuous CR in metabolic disorders such as diabetes. Methods In this study, we analyzed two protocols of intermittent CR with the calorie-matched continuous CR in two diabetic mouse models including db/db and streptozotocin-treated mice. Intermittent CR was carried out by a fasting-mimicking diet (FMD, with 30% calorie intake of the control per day) for 2 days or 5 days (i.e., 2-5 or 5-9 regimes followed by free eating for 5 or 9 days respectively). Results In the two diabetic mouse models, both intermittent CR and continuous CR significantly reduced fasting blood glucose level and improved insulin sensitivity. However, intermittent CR performed significantly better than continuous CR in improving glycemic control and insulin sensitivity in db/db mice. In addition, intermittent CR improved the glucose homeostasis of the db/db mice without causing loss of body weight. Analyses with the pancreatic islets reveal that intermittent CR profoundly elevated the number of insulin-positive cells in both diabetic mouse models. Conclusions Our study indicated that both intermittent CR and continuous CR can lower fasting blood glucose level in the diabetic mice, while intermittent CR is better than the latter in improving glucose homeostasis in db/db mice.

关键词Diabetes Intermittent fasting Fasting-mimicking diet Calorie restriction Insulin sensitivity
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收录类别SCI ; SCIE
语种英语
资助项目Chinese Academy of Sciences[XDA12010102] ; Chinese Academy of Sciences[QYZDJ-SSW-SMC008] ; Chinese Academy of Sciences[ZDRW-ZS-2016-8]
WOS研究方向Nutrition & Dietetics
WOS类目Nutrition & Dietetics
WOS记录号WOS:000483053900001
出版者BMC
WOS关键词DIET ; REGENERATION
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/66395
专题生命科学与技术学院_硕士生
生命科学与技术学院_特聘教授组_陈雁组
生命科学与技术学院_博士生
通讯作者Chen, Yan
作者单位
1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位生命科学与技术学院
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GB/T 7714
Wei, Siying,Zhao, Jingyu,Bai, Meijuan,et al. Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice[J]. NUTRITION & METABOLISM,2019,16(1).
APA Wei, Siying,Zhao, Jingyu,Bai, Meijuan,Li, Chenchen,Zhang, Lingling,&Chen, Yan.(2019).Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice.NUTRITION & METABOLISM,16(1).
MLA Wei, Siying,et al."Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice".NUTRITION & METABOLISM 16.1(2019).
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