Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons

doi:10.3389/fnins.2019.00565

	Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons
	Zhang, Shouhua1,2,3,4 ; Lv, Fei3,4,5,6 ; Yuan, Yuan3,4,6 ; Fan, Chengyu3 ; Li, Jiang 1,2; Sun, Wenzhi3,5,7 ; Hu, Ji3
	2019-06-04
发表期刊	FRONTIERS IN NEUROSCIENCE
ISSN	1662-453X
卷号	13
发表状态	已发表
DOI	10.3389/fnins.2019.00565
摘要	Corticotropin-releasing hormone (CRH) is a critical neuropeptide modulating the mammalian stress response. It is involved in many functional activities within various brain regions, among which there is a subset of CRH neurons occupying a considerable proportion of the cortical GABAergic interneurons. Here, we utilized rabies virus-based monosynaptic retrograde tracing system to map the whole-brain afferent presynaptic partners of the CRH neurons in the anterior cingulate cortex (ACC). We find that the ACC CRH neurons integrate information from the cortex, thalamus, hippocampal formation, amygdala, and also several other midbrain and hindbrain nuclei. Furthermore, our results reveal that ACC CRH neurons receive direct inputs from two neuromodulatory systems, the basal forebrain cholinergic neurons and raphe serotoninergic neurons. These findings together expand our knowledge about the connectivity of the cortical GABAergic neurons and also provide a basis for further investigation of the circuit function of cortical CRH neurons.
关键词	corticotropin-releasing hormone the anterior cingulate cortex whole-brain mapping monosynaptic inputs rabies virus
收录类别	SCI ; SCIE ; SSCI
语种	英语
资助项目	Shanghai Pujiang Talent Award[2018X0302-101-01]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000470217400002
出版者	FRONTIERS MEDIA SA
WOS关键词	ANTERIOR CINGULATE CORTEX ; CORTICOTROPIN-RELEASING-FACTOR ; INTERNEURON DIVERSITY SERIES ; NUCLEUS BASALIS ; MOUSE MODEL ; SEROTONIN ; STRESS ; PAIN ; DORSAL ; DOPAMINE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/48983
专题	生命科学与技术学院_硕士生生命科学与技术学院_PI研究组_胡霁组生命科学与技术学院_公共科研平台_分子影像平台 iHuman研究所_PI研究组_孙文智组生命科学与技术学院_博士生
通讯作者	Hu, Ji
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 6.Chinese Acad Sci, Inst Neurosci, Shanghai, Peoples R China 7.Chinese Inst Brain Res, Beijing, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Shouhua,Lv, Fei,Yuan, Yuan,et al. Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons[J]. FRONTIERS IN NEUROSCIENCE,2019,13.
APA	Zhang, Shouhua.,Lv, Fei.,Yuan, Yuan.,Fan, Chengyu.,Li, Jiang.,...&Hu, Ji.(2019).Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.FRONTIERS IN NEUROSCIENCE,13.
MLA	Zhang, Shouhua,et al."Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons".FRONTIERS IN NEUROSCIENCE 13(2019).