Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting
Zhao, Zheng-dong1,2,3; Chen, Zongming1,2,4,5; Xiang, Xinkuan6,7,8; Hu, Mengna1,2,4,5; Xie, Hengchang1,2,4,5; Jia, Xiaoning1,2; Cai, Fang1,2; Cui, Yuting6,7,8; Chen, Zijun9; Qian, Lechen1,2
2019-06
发表期刊NATURE NEUROSCIENCE
ISSN1097-6256
卷号22期号:6页码:921-932
发表状态已发表
DOI10.1038/s41593-019-0404-5
摘要

The neural substrates for predatory hunting, an evolutionarily conserved appetitive behavior, remain largely undefined. Photoactivation of zona incerta (ZI) GABAergic neurons strongly promotes hunting of both live and artificial prey. Conversely, photoinhibition of these neurons or deletion of their GABA function severely impairs hunting. Here electrophysiological recordings reveal that ZI neurons integrate prey-related multisensory signals and discriminate prey from non-prey targets. Visual or whisker sensory deprivation reduces calcium responses induced by prey introduction and attack and impair hunting. ZI photoactivation largely corrects the hunting impairment caused by sensory deprivations. Motivational and reinforcing assays reveal that ZI photoactivation is associated with a strong appetitive drive, causing repetitive self-stimulatory behaviors. These ZI neurons project to the periaqueductal gray matter to induce hunting and motivation. Thus, we have delineated the function of ZI GABAergic neurons in hunting, which integrates prey-related sensory signals into prey detection and attack and induces a strong appetitive motivational drive.

收录类别SCI ; SCIE
资助项目Shanghai Pujiang Talent Award[2018X0302-101-01]
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000468883100011
出版者NATURE PUBLISHING GROUP
WOS关键词DEEP BRAIN-STIMULATION ; PREDATORY BEHAVIOR ; ACTIVATION ; LESIONS ; CONNECTIONS ; RETROGRADE ; PROJECTION ; AFFERENTS ; RECEPTORS ; SUBSECTOR
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/45632
专题生命科学与技术学院_PI研究组_沈伟组
生命科学与技术学院_PI研究组_胡霁组
免疫化学研究所
iHuman研究所_PI研究组_孙文智组
生命科学与技术学院_硕士生
生命科学与技术学院_博士生
生命科学与技术学院_本科生
共同第一作者Chen, Zongming
通讯作者Li, Haohong; Shen, Wei L.
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai, Peoples R China
4.Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan, Hubei, Peoples R China
7.Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Biomed Engn, Sch Engn Sci, MoE Key Lab Biomed Photon, Wuhan, Hubei, Peoples R China
8.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan, Hubei, Peoples R China
9.Natl Inst Biol Sci, Zhongguancun Life Sci Pk, Beijing, Peoples R China
第一作者单位生命科学与技术学院;  免疫化学研究所
通讯作者单位生命科学与技术学院;  免疫化学研究所
第一作者的第一单位生命科学与技术学院
推荐引用方式
GB/T 7714
Zhao, Zheng-dong,Chen, Zongming,Xiang, Xinkuan,et al. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting[J]. NATURE NEUROSCIENCE,2019,22(6):921-932.
APA Zhao, Zheng-dong.,Chen, Zongming.,Xiang, Xinkuan.,Hu, Mengna.,Xie, Hengchang.,...&Shen, Wei L..(2019).Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.NATURE NEUROSCIENCE,22(6),921-932.
MLA Zhao, Zheng-dong,et al."Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting".NATURE NEUROSCIENCE 22.6(2019):921-932.
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