Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking

doi:10.1038/s41598-017-08357-4

	Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking
	Zhang, Ye 1,2; Shen, Hao 1,2; Liu, Haifeng 1,2; Feng, Haiyun1,2,3 ; Liu, Yan1,2,3 ; Zhu, Xiaoyan 1,2; Liu, Xiaolong1,2,3
	2017-08-21
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7
发表状态	已发表
DOI	10.1038/s41598-017-08357-4
摘要	T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, results in compromised peripheral T cell homeostasis. Arp2/3 complex-nucleated actin filaments are essential for maintaining surface TCR levels by regulating TCR+ endosome trafficking in resting state and controlling polarization of TCR+ endosomes during immune synapse formation in T cells. Additionally, Arpc2-TKO T cells are unable to form immune synapse. Interestingly, defected T cell homeostasis is caused by reduced surface TCR levels but not impaired immune synapse formation. Collectively, our findings suggest that Arp2/3 complex-nucleated actin filaments are required for maintaining surface TCR levels via regulating TCR+ endosome trafficking which is essential for T cell homeostasis.
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000408107000086
出版者	NATURE PUBLISHING GROUP
WOS关键词	IMMUNE SYNAPSE ; IMMUNOLOGICAL SYNAPSE ; LIFE-SPAN ; RECEPTOR MICROCLUSTERS ; ACTIN NUCLEATION ; ADAPTER PROTEIN ; PRIMARY CILIUM ; ACTIVATION ; NAIVE ; MEMORY
原始文献类型	Article
通讯作者	Liu, Xiaolong
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4518
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_刘小龙组生命科学与技术学院_硕士生
通讯作者	Liu, Xiaolong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Ye,Shen, Hao,Liu, Haifeng,et al. Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking[J]. SCIENTIFIC REPORTS,2017,7.
APA	Zhang, Ye.,Shen, Hao.,Liu, Haifeng.,Feng, Haiyun.,Liu, Yan.,...&Liu, Xiaolong.(2017).Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking.SCIENTIFIC REPORTS,7.
MLA	Zhang, Ye,et al."Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking".SCIENTIFIC REPORTS 7(2017).