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| Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking | |
| 2017-08-21 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 7 |
| Status | 已发表 |
| DOI | 10.1038/s41598-017-08357-4 |
| Abstract | T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, results in compromised peripheral T cell homeostasis. Arp2/3 complex-nucleated actin filaments are essential for maintaining surface TCR levels by regulating TCR+ endosome trafficking in resting state and controlling polarization of TCR+ endosomes during immune synapse formation in T cells. Additionally, Arpc2-TKO T cells are unable to form immune synapse. Interestingly, defected T cell homeostasis is caused by reduced surface TCR levels but not impaired immune synapse formation. Collectively, our findings suggest that Arp2/3 complex-nucleated actin filaments are required for maintaining surface TCR levels via regulating TCR+ endosome trafficking which is essential for T cell homeostasis. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000408107000086 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | IMMUNE SYNAPSE ; IMMUNOLOGICAL SYNAPSE ; LIFE-SPAN ; RECEPTOR MICROCLUSTERS ; ACTIN NUCLEATION ; ADAPTER PROTEIN ; PRIMARY CILIUM ; ACTIVATION ; NAIVE ; MEMORY |
| Original Document Type | Article |
| Corresponding Author | Liu, Xiaolong |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4518 |
| Collection | 生命科学与技术学院 生命科学与技术学院_特聘教授组_刘小龙组 生命科学与技术学院_硕士生 |
| Corresponding Author | Liu, Xiaolong |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Zhang, Ye,Shen, Hao,Liu, Haifeng,et al. Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Zhang, Ye.,Shen, Hao.,Liu, Haifeng.,Feng, Haiyun.,Liu, Yan.,...&Liu, Xiaolong.(2017).Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking.SCIENTIFIC REPORTS,7. |
| MLA | Zhang, Ye,et al."Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking".SCIENTIFIC REPORTS 7(2017). |
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