Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position

doi:10.1002/adsc.201700484

	*CpRh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position**
	Wang, Bao1,2,3 ; Li, Chunpu 2,3; Liu, Hong1,2,3
	2017-09-04
发表期刊	ADVANCED SYNTHESIS & CATALYSIS (IF:4.4[JCR-2023],4.6[5-Year])
ISSN	1615-4150
EISSN	1615-4169
卷号	359 期号:17 页码:3029-3034
发表状态	已发表
DOI	10.1002/adsc.201700484
摘要	Herein, we report a Cp*Rh(III)-catalyzed directed C-H methylation of quinoline N-oxides at the C-8 position using commercially available organotrifluoroborates as reagents. This method features perfect regioselectivity, relatively mild reaction conditions, and diverse functional group tolerance with good to excellent yields. Additionally, direct C-8 arylated quinoline N-oxides products could also be obtained under the same conditions. Preliminary mechanistic experiments were conducted and a possible mechanism was proposed.
关键词	Quinoline N-Oxides C-H Methylation Rhodium
收录类别	SCI ; IC ; CCR
语种	英语
资助项目	National S&T Major Projects[2014ZX09507002-001]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000408941200017
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	CROSS-COUPLING REACTION ; BOND ACTIVATION ; BORONIC ACIDS ; MILD CONDITIONS ; FUNCTIONALIZATION ; ALKYLATION ; ALKYNES ; ARENES ; HETEROARENES ; DISCOVERY
原始文献类型	Article
通讯作者	Liu, Hong
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4502
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_柳红组生命科学与技术学院_博士生
通讯作者	Liu, Hong
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Bao,Li, Chunpu,Liu, Hong. Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(17):3029-3034.
APA	Wang, Bao,Li, Chunpu,&Liu, Hong.(2017).Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position.ADVANCED SYNTHESIS & CATALYSIS,359(17),3029-3034.
MLA	Wang, Bao,et al."Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position".ADVANCED SYNTHESIS & CATALYSIS 359.17(2017):3029-3034.