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Rh(III)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks 期刊论文
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 8
作者:  Hu, Shulei;  Zhang, Yu;  Xie, Xiong;  Li, Luhan;  Chen, Kaixian
Adobe PDF(2002Kb)  |  收藏  |  浏览/下载:116/1  |  提交时间:2024/10/14
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 页码: 1651-1664
作者:  xiexiong;  Qiaoshuai Lan;  Jinyi Zhao;  Sulin Zhang;  Liu L(刘露)
Adobe PDF(4198Kb)  |  收藏  |  浏览/下载:93/12  |  提交时间:2024/12/02
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2
作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke
Adobe PDF(7268Kb)  |  收藏  |  浏览/下载:242/2  |  提交时间:2024/03/04
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4) 期刊论文
NATURE COMMUNICATIONS;, 2023, 卷号: 14, 期号: 1
作者:  Chen, Yan;  Zhou, Qingtong;  Wang, Jiang;  Xu, Youwei;  Wang, Yun
Adobe PDF(5601Kb)  |  收藏  |  浏览/下载:1196/230  |  提交时间:2023/03/24
一种三环类化合物、其制备方法及其应用 专利
申请号:CN202211132254.X,申请日期: 2023-01-03,类型:发明申请,状态:授权
发明人:  白芳;  柳红;  许叶春;  张磊砢;  任鹏璇
Unknown(3830Kb)  |  收藏  |  浏览/下载:595/0  |  提交时间:2023/01/03
Construction of Vinyl-Substituted N-Heterocycles via Rh(III)- Catalyzed C-H Functionalization/Annulation of Pyrazolidinones 期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2023
作者:  Zhang, Shurui;  Hu, Shulei;  Wang, Kean;  Yang, Zhao;  Liu, Hong
Adobe PDF(6743Kb)  |  收藏  |  浏览/下载:229/0  |  提交时间:2023/02/24
A unique peptide recognition mechanism by the human relaxin family peptide receptor 4 (RXFP4) 预印本
2022
作者:  Chen, Y.;  Zhou, Q.;  Wang, J.;  Xu, Y.;  Wang, Y.
Adobe PDF(3244Kb)  |  收藏  |  浏览/下载:341/64  |  提交时间:2024/01/09
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11
作者:  Zhang, Shurui;  Chen, Xiaoxu;  Wu, Chenglin;  Xu, Hui;  Xie, Xiong
Adobe PDF(11423Kb)  |  收藏  |  浏览/下载:340/0  |  提交时间:2022/07/01
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong
Adobe PDF(5151Kb)  |  收藏  |  浏览/下载:330/0  |  提交时间:2021/11/19
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215
作者:  Gao, Feng;  Chen, Xiaoxu;  Lu, Junyan;  Hu, Shulei;  Xu, Hui
Adobe PDF(2015Kb)  |  收藏  |  浏览/下载:378/1  |  提交时间:2021/04/30