ShanghaiTech University Knowledge Management System
| Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1 | |
| 2024 | |
| 发表期刊 | ADVANCED SCIENCE (IF:14.3[JCR-2023],16.3[5-Year]) |
| ISSN | 2198-3844 |
| EISSN | 2198-3844 |
| 卷号 | 11期号:14 |
| 发表状态 | 已发表 |
| DOI | 10.1002/advs.202306311 |
| 摘要 | The G-protein-coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1-Gi complexes in synthetic agonist-bound forms have been resolved to date. However, the commercial drug recognition and Gq coupling mechanisms of CB1 remain elusive. Herein, the cryo-electron microscopy (cryo-EM) structure of CB1-Gq complex, in fenofibrate-bound form, at near-atomic resolution, is reported. The structure elucidates the delicate mechanisms of the precise fenofibrate recognition and Gq protein coupling by CB1 and will facilitate future drug discovery and design. |
| 关键词 | Cryo-electron microscopy Cannabinoid receptors Coupling mechanism Fenofibrate Electron microscopes Electron microscopy Medical imaging G protein Gq coupling Human cannabinoid receptor 1 Human cannabinoid receptors Ligand recognition Receptor-1 |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| 出版者 | John Wiley and Sons Inc |
| EI入藏号 | 20240615494188 |
| EI主题词 | Proteins |
| EI分类号 | 461.1 Biomedical Engineering ; 746 Imaging Techniques ; 804.1 Organic Compounds |
| 原始文献类型 | Journal article (JA) |
| 引用统计 | 正在获取...
|
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/421479 |
| 专题 | iHuman研究所 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 |
| 共同第一作者 | Tang, Wenqin; Zhao, Ziyi; Zhao, Ran; Lv, Zhenyu |
| 通讯作者 | Li, Fahui; Wang, Jiangyun |
| 作者单位 | 1.CAS Key Laboratory of Quantitative Engineering Biology, Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen; 518055, China 2.iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, Pudong; 201210, China 3.Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, Chaoyang District; 100101, China 4.School of Life Sciences, University of Chinese Academy of Sciences, Beijing; 100049, China 5.Key Laboratory of Biomacromolecules, Chinese Academy of Sciences, Beijing; 100101, China |
| 第一作者单位 | iHuman研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Tianxin,Tang, Wenqin,Zhao, Ziyi,et al. Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1[J]. ADVANCED SCIENCE,2024,11(14). |
| APA | Wang, Tianxin.,Tang, Wenqin.,Zhao, Ziyi.,Zhao, Ran.,Lv, Zhenyu.,...&Wang, Jiangyun.(2024).Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1.ADVANCED SCIENCE,11(14). |
| MLA | Wang, Tianxin,et al."Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1".ADVANCED SCIENCE 11.14(2024). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
修改评论
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。