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| Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93Amouse G93A mouse model of amyotrophic lateral sclerosis | |
| 2024-09-24 | |
| 发表期刊 | CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year]) |
| ISSN | 2211-1247 |
| 卷号 | 43期号:9 |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.celrep.2024.114660 |
| 摘要 | Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord, and there are no effective drug treatments. Low-intensity pulsed ultrasound (LIPUS) has garnered attention as a promising noninvasive neuromodulation method. In this study, we investigate its effects on the motor cortex and underlying mechanisms using the SOD1G93A G93A mouse model of ALS. Our results show that LIPUS treatment delays disease onset and prolongs lifespan in ALS mice. LIPUS significantly increases cerebral blood flow in the motor cortex by preserving vascular endothelial cell integrity and increasing microvascular density, which may be mediated via the ion channel TRPV4. RNA sequencing analysis reveals that LIPUS substantially reduces the expression of genes associated with neuroinflammation. These findings suggest that LIPUS applied to the motor cortex may represent a potentially effective therapeutic tool for the treatment of ALS. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Interdisciplinary Program of Shanghai Jiao Tong University[YG2023QNB18] ; Key Program of National Natural Science Foundation of China[82030050] ; National Natural Science Foundation of China[T2394534] ; Key Project of Shanghai Municipal Commission of Science and Technology[ |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| WOS记录号 | WOS:001301206900001 |
| 出版者 | CELL PRESS |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/421334 |
| 专题 | iHuman研究所 生命科学与技术学院 iHuman研究所_特聘教授组_Raymond Stevens组 iHuman研究所_PI研究组_Garth John Thompson组 生命科学与技术学院_硕士生 |
| 通讯作者 | Jiang, Lixian; Zheng, Yuanyi; Zhang, Xiaojie |
| 作者单位 | 1.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Neurol, Sch Med, Shanghai 200233, Peoples R China 2.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Ultrasonog, Sch Med, Shanghai 200233, Peoples R China 3.Shanghai Neurol Rare Dis Biobank & Precis Diagnos, Shanghai 200233, Peoples R China 4.Natl Innovat Ctr par Excellence, Inst Adv Ultrason Technol, Shanghai 201203, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Medx Engn Res Ctr, Sch Biomed Engn, Shanghai 200030, Peoples R China 6.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 8.East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ct, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zihao,Zhang, Huan,Lu, Kaili,et al. Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93Amouse G93A mouse model of amyotrophic lateral sclerosis[J]. CELL REPORTS,2024,43(9). |
| APA | Liu, Zihao.,Zhang, Huan.,Lu, Kaili.,Chen, Li.,Zhang, Yueqi.,...&Zhang, Xiaojie.(2024).Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93Amouse G93A mouse model of amyotrophic lateral sclerosis.CELL REPORTS,43(9). |
| MLA | Liu, Zihao,et al."Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93Amouse G93A mouse model of amyotrophic lateral sclerosis".CELL REPORTS 43.9(2024). |
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