上海科技大学知识管理系统

本发明公开了式(I)化合物或其盐、对映异构体、立体异构体、溶剂化物、富含同位素的类似物、前药或多晶型物及其应用。 还公开了包含式(I)化合物或其盐、对映异构体、立体异构体、溶剂化物、富含同位素的类似物、前药或多晶型物作为活性成分的药物组合物及其应用。 设计和合成的一系列化合物可以有效地预防和//或治疗与NAMPT相关的疾病或病症。

Disclosed are a compound of formula (I) or a salt, enantiomer, stereoisomer, solvate, isotope-enriched analogue, prodrug or polymorph thereof, and an application thereof. Also disclosed are a pharmaceutical composition comprising the compound of formula (I) as an active ingredient or the salt, enantiomer, stereoisomer, solvate, the isotope-enriched analogue, the prodrug or the polymorph thereof, and an application thereof. A series of compounds designed and synthesized can effectively prevent and//or treat diseases or conditions associated with NAMPT.