Mammillary body regulates state-dependent fear by alternating cortical oscillations

doi:10.1038/s41598-018-31622-z

	Mammillary body regulates state-dependent fear by alternating cortical oscillations
	Jiang, Jun1,3 ; Wang, Guang-Yu 1,3; Luo, Wenhan 1,2,4; Xie, Hong 1,5; Guan, Ji-Song1,3,6
	2018-09-07
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	8
发表状态	已发表
DOI	10.1038/s41598-018-31622-z
摘要	State-dependent memory describes a phenomenon that memory will be efficiently retrieved only when the brain state during retrieval matches the state during encoding. While a variety of psychoactive drugs, such as ethanol, cocaine, morphine and NMDA receptor antagonists, are able to induce state-dependent memory, the biological hallmark of brain state and neural mechanism of its regulation are still unknown. In this study, we found that MK-801 enhanced delta oscillations in awake mice, representing a drug-induced brain state, in which fear memory could only be successfully retrieved when the same drug condition was presented. We identified a key nucleus, mammillary body (MB), which regulates the specific brain state associated with MK-801. Chemogenetic silencing of MB neurons enhanced cortical delta oscillations and generated state-dependent memory. Moreover, optogenetic reconstitution of delta oscillations alone facilitated retrieval of fear memory encoded under MK-801. Our results indicated that delta oscillations in awake animals defined a specific brain state, in which memory formed is inaccessible under the normal condition, shining light on the neural mechanism underlying the fluctuation of memory retrieval and the role of MB in memory encoding and recall.
收录类别	SCI ; SCIE ; SSCI
语种	英语
资助项目	German Research Foundation (DFG) in project Crossmodal Learning, NSFC[(61621136008)/DGF TRR-169]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000444024100006
出版者	NATURE PUBLISHING GROUP
WOS关键词	THETA OSCILLATIONS ; THALAMOCORTICAL NEURONS ; KORSAKOFF SYNDROME ; PASSIVE-AVOIDANCE ; SLOW OSCILLATIONS ; INDUCED LESIONS ; NMDA RECEPTORS ; SPATIAL MEMORY ; MK-801 ; BRAIN
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27775
专题	生命科学与技术学院_PI研究组_管吉松组生命科学与技术学院_硕士生
通讯作者	Guan, Ji-Song
作者单位	1.Tsinghua Univ, Sch Life Sci, Beijing 100086, Peoples R China 2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 5.Inst Brain Intelligence Sci & Technol, Zhangjiang Lab, Shanghai 200031, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Jiang, Jun,Wang, Guang-Yu,Luo, Wenhan,et al. Mammillary body regulates state-dependent fear by alternating cortical oscillations[J]. SCIENTIFIC REPORTS,2018,8.
APA	Jiang, Jun,Wang, Guang-Yu,Luo, Wenhan,Xie, Hong,&Guan, Ji-Song.(2018).Mammillary body regulates state-dependent fear by alternating cortical oscillations.SCIENTIFIC REPORTS,8.
MLA	Jiang, Jun,et al."Mammillary body regulates state-dependent fear by alternating cortical oscillations".SCIENTIFIC REPORTS 8(2018).