ShanghaiTech University Knowledge Management System
| Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein | |
| 2022-11-04 | |
| 发表期刊 | COMMUNICATIONS BIOLOGY (IF:5.2[JCR-2023],5.6[5-Year]) |
| EISSN | 2399-3642 |
| 卷号 | 5期号:1 |
| 发表状态 | 已发表 |
| DOI | 10.1038/s42003-022-04160-8 |
| 摘要 | ["Understanding the antigenic signatures of all human coronaviruses (HCoVs) Spike (S) proteins is imperative for pan-HCoV epitopes identification and broadly effective vaccine development. To depict the currently elusive antigenic signatures of alpha-HCoVs S proteins, we isolated a panel of antibodies against the HCoV-229E S protein and characterized their epitopes and neutralizing potential. We found that the N-terminal domain of HCoV-229E S protein is antigenically dominant wherein an antigenic supersite is present and appears conserved in HCoV-NL63, which holds potential to serve as a pan-alpha-HCoVs epitope. In the receptor binding domain, a neutralizing epitope is captured in the end distal to the receptor binding site, reminiscent of the locations of the SARS-CoV-2 RBD cryptic epitopes. We also identified a neutralizing antibody that recognizes the connector domain, thus representing the first S2-directed neutralizing antibody against alpha-HCoVs. The unraveled HCoVs S proteins antigenic similarities and variances among genera highlight the challenges faced by pan-HCoV vaccine design while supporting the feasibility of broadly effective vaccine development against a subset of HCoVs.","The antigenic landscape of alpha-HCoVs S proteins is revealed, highlighting the challenges faced by pan-HCoV vaccine design but also revealing opportunities for development of broadly effective vaccines against a subset of HCoVs."] |
| URL | 查看原文 |
| 收录类别 | SCI ; SCIE |
| 语种 | 英语 |
| 资助项目 | Ministry of Science and Technology of China[2018ZX10731-101-001-010] ; National Natural Science Foundation of China (NSFC)["32070170","82041036"] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| WOS类目 | Biology ; Multidisciplinary Sciences |
| WOS记录号 | WOS:000879050900004 |
| 出版者 | NATURE PORTFOLIO |
| Scopus 记录号 | 2-s2.0-85141211171 |
| 来源库 | Scopus |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/248884 |
| 专题 | 免疫化学研究所_PI研究组_杨贝组 生命科学与技术学院_PI研究组_陈佳组 免疫化学研究所_特聘教授组_抗体工程学实验室 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 |
| 通讯作者 | Lu, Lu; Miersch, Shane; Yang, Bei |
| 作者单位 | 1.School of Life Science and Technology and Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai,393 Middle Huaxia Road,201210,China 2.CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai,320 Yueyang Road,200031,China 3.University of Chinese Academy of Sciences,Beijing,19 Yuquan Road,100049,China 4.Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS),School of Basic Medical Sciences,Shanghai Institute of Infectious Disease and Biosecurity,Fudan University,Shanghai,130 Dong An Road,200032,China 5.The Anvil Institute,School of Pharmacy,University of Waterloo,Kitchener,151 Charles St. W,N2G 1H6,Canada 6.Shanghai Clinical Research and Trial Center,Shanghai,201210,China |
| 第一作者单位 | 免疫化学研究所 |
| 通讯作者单位 | 免疫化学研究所 |
| 第一作者的第一单位 | 免疫化学研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, Jiangchao,Su, Jie,Lan, Qiaoshuai,et al. Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein[J]. COMMUNICATIONS BIOLOGY,2022,5(1). |
| APA | Xiang, Jiangchao.,Su, Jie.,Lan, Qiaoshuai.,Zhao, Wenwen.,Zhou, Yu.,...&Yang, Bei.(2022).Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein.COMMUNICATIONS BIOLOGY,5(1). |
| MLA | Xiang, Jiangchao,et al."Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein".COMMUNICATIONS BIOLOGY 5.1(2022). |
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