Molecular Insights into mRNA Polyadenylation and Deadenylation

doi:10.3390/ijms231910985

	Molecular Insights into mRNA Polyadenylation and Deadenylation
	Liu, Junjie; Lu, Xubing; Zhang, Siyu; Yuan, Ling; Sun, Yadong
	2022-10
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (IF:4.9[JCR-2023],5.6[5-Year])
EISSN	1422-0067
卷号	23 期号:19
DOI	10.3390/ijms231910985
摘要	Poly(A) tails are present on almost all eukaryotic mRNAs, and play critical roles in mRNA stability, nuclear export, and translation efficiency. The biosynthesis and shortening of a poly(A) tail are regulated by large multiprotein complexes. However, the molecular mechanisms of these protein machineries still remain unclear. Recent studies regarding the structural and biochemical characteristics of those protein complexes have shed light on the potential mechanisms of polyadenylation and deadenylation. This review summarizes the recent structural studies on pre-mRNA 3'-end processing complexes that initiate the polyadenylation and discusses the similarities and differences between yeast and human machineries. Specifically, we highlight recent biochemical efforts in the reconstitution of the active human canonical pre-mRNA 3'-end processing systems, as well as the roles of RBBP6/Mpe1 in activating the entire machinery. We also describe how poly(A) tails are removed by the PAN2-PAN3 and CCR4-NOT deadenylation complexes and discuss the emerging role of the cytoplasmic poly(A)-binding protein (PABPC) in promoting deadenylation. Together, these recent discoveries show that the dynamic features of these machineries play important roles in regulating polyadenylation and deadenylation.
关键词	poly(A) tail polyadenylation deadenylation 3 '-end processing RBBP6/Mpe1 PAN2-PAN3 CCR4-NOT PABPC RNA-binding protein
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收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000867760400001
出版者	MDPI
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/243315
专题	生命科学与技术学院_博士生生命科学与技术学院_硕士生生命科学与技术学院_PI研究组_孙亚东组
通讯作者	Sun, Yadong
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Junjie,Lu, Xubing,Zhang, Siyu,et al. Molecular Insights into mRNA Polyadenylation and Deadenylation[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(19).
APA	Liu, Junjie,Lu, Xubing,Zhang, Siyu,Yuan, Ling,&Sun, Yadong.(2022).Molecular Insights into mRNA Polyadenylation and Deadenylation.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(19).
MLA	Liu, Junjie,et al."Molecular Insights into mRNA Polyadenylation and Deadenylation".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.19(2022).