Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis

doi:10.1038/s41467-022-32325-w

	Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis
	Bao, Wenjie 1; Xing, Huayue 1; Cao, Shiwei2 ; Long, Xin 3; Liu, Haifeng 1; Ma, Junwei 1; Guo, Fan 3,4; Deng, Zimu 1; Liu, Xiaolong1,2,5
	2022-08-06
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-32325-w
摘要	Disseminated intravascular coagulation (DIC) is a complication of sepsis currently lacking effective therapeutic options. Excessive inflammatory responses are emerging triggers of coagulopathy during sepsis, but the interplay between the immune system and coagulation are not fully understood. Here we utilize a murine model of intraperitoneal lipopolysaccharide stimulation and show neutrophils in the circulation mitigate the occurrence of DIC, preventing subsequent septic death. We show circulating neutrophils release extracellular vesicles containing mitochondria, which contain superoxide dismutase 2 upon exposure to lipopolysaccharide. Extracellular superoxide dismutase 2 is necessary to induce neutrophils’ antithrombotic function by preventing endothelial reactive oxygen species accumulation and alleviating endothelial dysfunction. Intervening endothelial reactive oxygen species accumulation by antioxidants significantly ameliorates disseminated intravascular coagulation improving survival in this murine model of lipopolysaccharide challenge. These findings reveal an interaction between neutrophils and vascular endothelium which critically regulate coagulation in a model of sepsis and may have potential implications for the management of disseminated intravascular coagulation.
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收录类别	SCIE
语种	英语
Scopus 记录号	2-s2.0-85135477474
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214814
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_刘小龙组生命科学与技术学院_博士生
通讯作者	Deng, Zimu; Liu, Xiaolong
作者单位	1.State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,Yueyang Road,320,China 2.School of Life Science and Technology,Shanghai Tech University,Shanghai,200031,China 3.State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing,100101,China 4.Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing,100101,China 5.Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,310024,China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Bao, Wenjie,Xing, Huayue,Cao, Shiwei,et al. Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Bao, Wenjie.,Xing, Huayue.,Cao, Shiwei.,Long, Xin.,Liu, Haifeng.,...&Liu, Xiaolong.(2022).Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis.NATURE COMMUNICATIONS,13(1).
MLA	Bao, Wenjie,et al."Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis".NATURE COMMUNICATIONS 13.1(2022).