Immunomodulation of artemisinin and its derivatives

doi:10.1007/s11434-016-1105-z

	Immunomodulation of artemisinin and its derivatives
	Yao, Wenbo 1,2; Wang, Feng3 ; Wang, Hui1,2,3,4
	2016-09
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	61 期号:18 页码:1399-1406
发表状态	已发表
DOI	10.1007/s11434-016-1105-z
摘要	In the 1970s, artemisinin ("qinghaosu" in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. For more than 30 years, artemisinin has contributed to worldwide health as a new type of antimalarial drug. Artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside, artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer, and anti-inflammatory properties. In this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.
关键词	Artemisinin Immune system Immune-related diseases Macrophage T-cell B-cell
收录类别	SCI ; CSCD ; EI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[14391901800]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000384566600002
CSCD记录号	CSCD:5814555
出版者	ELSEVIER SCIENCE BV
EI入藏号	20162502522721
EI主题词	Macrophages ; T-cells
WOS关键词	NF-KAPPA-B ; ANTIMALARIAL AGENT ARTESUNATE ; ESCHERICHIA-COLI CHALLENGE ; COLLAGEN-INDUCED ARTHRITIS ; MESSENGER-RNA EXPRESSIONS ; T-CELL-ACTIVATION ; SEPSIS MODEL MICE ; IN-VITRO ; TNF-ALPHA ; ANTIINFLAMMATORY PROPERTIES
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1716
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_王慧组生命科学与技术学院_硕士生
通讯作者	Wang, Hui
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yao, Wenbo,Wang, Feng,Wang, Hui. Immunomodulation of artemisinin and its derivatives[J]. SCIENCE BULLETIN,2016,61(18):1399-1406.
APA	Yao, Wenbo,Wang, Feng,&Wang, Hui.(2016).Immunomodulation of artemisinin and its derivatives.SCIENCE BULLETIN,61(18),1399-1406.
MLA	Yao, Wenbo,et al."Immunomodulation of artemisinin and its derivatives".SCIENCE BULLETIN 61.18(2016):1399-1406.