A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1

doi:10.1038/s42003-022-03263-6

	A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1
	Yang, Yifeng1 ; Lu, Wenwen2 ; Ning, Mei 3,4; Zhou, Xianhao1 ; Wan, Xinyao1 ; Mi, Qianglong1 ; Yang, Xiaoyan2 ; Zhang, Di 3,4; Zhang, Yuanyuan1 ; Jiang, Biao1 ; He, Lin 3,4; Liu, Jia1,2,5 ; Zou, Yan2
	2022-04-04
发表期刊	COMMUNICATIONS BIOLOGY (IF:5.2[JCR-2023],5.6[5-Year])
ISSN	2399-3642
EISSN	2399-3642
卷号	5 期号:1 页码:309
发表状态	已发表
DOI	10.1038/s42003-022-03263-6
摘要	The aberrant expression or genomic mutations of microRNA are associated with several human diseases. This study analyzes the relationship between genetic variations of miRNA and schizophrenia or bipolar disorder. We performed case-control studies for ten SNPs in a total sample of 1584 subjects. All these ten SNPs were on or near mature microRNAs. We identified the association between bipolar disorder and the T/C polymorphism at rs895819. To illustrate the function of miR-27a, we constructed several miR-27a knockout (KO) cell lines, determined candidates of miR-27a, and then verified NCAM1 as a target gene of miR-27a. Further studies revealed that the T/C polymorphism on miR-27a led to the differential expression of mature and precursor miR-27a without affecting the expression of primary miR-27a. Furthermore, the C mutation on pre-miR-27a suppresses cell migration and dopamine expression levels. Our study highlights the importance of miR-27a and its polymorphism at rs895819 in bipolar disorder.
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收录类别	SCIE ; SSCI
语种	英语
Scopus 记录号	2-s2.0-85127467091
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/171518
专题	生命科学与技术学院_PI研究组_邹燕组免疫化学研究所_特聘教授组_抗体化学实验室生命科学与技术学院_硕士生生命科学与技术学院_博士生免疫化学研究所_PI研究组_刘佳组
通讯作者	Yang, Yifeng; Liu, Jia; Zou, Yan
作者单位	1.Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai,393 Middle Huaxia Road,201210,China 2.School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China 3.Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education),Bio-X Institutes,Shanghai Jiao Tong University,Shanghai,1954 HuaShan Road,200030,China 4.Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China 5.Shanghai Clinical Research and Trial Center,Shanghai,China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Yang, Yifeng,Lu, Wenwen,Ning, Mei,et al. A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1[J]. COMMUNICATIONS BIOLOGY,2022,5(1):309.
APA	Yang, Yifeng.,Lu, Wenwen.,Ning, Mei.,Zhou, Xianhao.,Wan, Xinyao.,...&Zou, Yan.(2022).A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1.COMMUNICATIONS BIOLOGY,5(1),309.
MLA	Yang, Yifeng,et al."A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1".COMMUNICATIONS BIOLOGY 5.1(2022):309.