ShanghaiTech University Knowledge Management System
Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces | |
2018-02-05 | |
发表期刊 | ADVANCED OPTICAL MATERIALS |
ISSN | 2195-1071 |
卷号 | 6期号:3 |
发表状态 | 已发表 |
DOI | 10.1002/adom.201700941 |
摘要 | Advanced optical fibers and photonic structures play important roles in neuroscience research, along with recent progresses of genetically encoded optical actuators and indicators. Most techniques for optical neural implants rely on fused silica or long-lasting polymeric fiber structures. In this paper, implantable and biodegradable optical fibers based on poly(l-lactic acid) (PLLA) are presented. PLLA fibers with dimensions similar to standard silica fibers are constructed using a simple thermal drawing process at around 220 degrees C. The formed PLLA fibers exhibit high mechanical flexibility and optical transparency, and their structural evolution and optical property changes are systematically studied during in vitro degradation. In addition, their biocompatibility with brain tissues is evaluated in living mice, and full in vivo degradation is demonstrated. Finally, PLLA fibers are implemented as a tool for intracranial light delivery and detection, realizing deep brain fluorescence sensing and optogenetic interrogation in vivo. The presented materials and device platform offer paths to fully biocompatible and bioresorbable photonic systems for biomedical uses.;Advanced optical fibers and photonic structures play important roles in neuroscience research, along with recent progresses of genetically encoded optical actuators and indicators. Most techniques for optical neural implants rely on fused silica or long-lasting polymeric fiber structures. In this paper, implantable and biodegradable optical fibers based on poly(l-lactic acid) (PLLA) are presented. PLLA fibers with dimensions similar to standard silica fibers are constructed using a simple thermal drawing process at around 220 degrees C. The formed PLLA fibers exhibit high mechanical flexibility and optical transparency, and their structural evolution and optical property changes are systematically studied during in vitro degradation. In addition, their biocompatibility with brain tissues is evaluated in living mice, and full in vivo degradation is demonstrated. Finally, PLLA fibers are implemented as a tool for intracranial light delivery and detection, realizing deep brain fluorescence sensing and optogenetic interrogation in vivo. The presented materials and device platform offer paths to fully biocompatible and bioresorbable photonic systems for biomedical uses. |
关键词 | biodegradable devices biodegradable devices fluorescence detection fluorescence detection implantable devices implantable devices optical fibers optical fibers optogenetics optogenetics |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China (NSFC)[51602172] ; National Natural Science Foundation of China (NSFC)[51602172] ; National Natural Science Foundation of China (NSFC)[51601103] ; National Natural Science Foundation of China (NSFC)[51601103] |
WOS研究方向 | Materials Science ; Materials Science ; Optics ; Optics |
WOS类目 | Materials Science, Multidisciplinary ; Materials Science, Multidisciplinary ; Optics ; Optics |
WOS记录号 | WOS:000424153300008 |
出版者 | WILEY-V C H VERLAG GMBH |
EI入藏号 | 20180604770392 |
EI主题词 | Biocompatibility ; Biocompatibility ; Biodegradation ; Biodegradation ; Biological materials ; Biological materials ; Fibers ; Fibers ; Fluorescence ; Fluorescence ; Fused silica ; Fused silica ; Implants (surgical) ; Implants (surgical) ; Lactic acid ; Lactic acid ; Optical fibers ; Optical fibers ; Optical properties ; Optical properties ; Silica ; Silica |
EI分类号 | Bioengineering and Biology:461 ; Bioengineering and Biology:461 ; Prosthetics:462.4 ; Prosthetics:462.4 ; Light/Optics:741.1 ; Light/Optics:741.1 ; Fiber Optics:741.1.2 ; Fiber Optics:741.1.2 ; Organic Compounds:804.1 ; Organic Compounds:804.1 ; Glass:812.3 ; Glass:812.3 |
WOS关键词 | HYDROLYTIC DEGRADATION ; HYDROLYTIC DEGRADATION ; REACTIVE GLIOSIS ; REACTIVE GLIOSIS ; WAVE-GUIDES ; WAVE-GUIDES ; IN-VIVO ; IN-VIVO ; KINETICS ; KINETICS ; BRAIN ; BRAIN ; OPTOGENETICS ; OPTOGENETICS ; POLYLACTIDES ; POLYLACTIDES ; ELECTRONICS ; ELECTRONICS ; HYDROGELS ; HYDROGELS |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16235 |
专题 | 生命科学与技术学院_PI研究组_管吉松组 |
通讯作者 | Guan, Jisong; Sheng, Xing |
作者单位 | 1.Tsinghua Univ, TNList, Dept Elect Engn, Beijing 100084, Peoples R China 2.Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China 3.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 5.Tsinghua Univ, Sch Life Sci, IDG McGovern Inst Brain Res Tsinghua, MOE Key Lab Prot Sci,Ctr Brain Inspired Comp, Beijing 100084, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Fu, Ruxing,Luo, Wenhan,Nazempour, Roya,et al. Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces[J]. ADVANCED OPTICAL MATERIALS,2018,6(3). |
APA | Fu, Ruxing.,Luo, Wenhan.,Nazempour, Roya.,Tan, Daxin.,Ding, He.,...&Sheng, Xing.(2018).Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces.ADVANCED OPTICAL MATERIALS,6(3). |
MLA | Fu, Ruxing,et al."Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces".ADVANCED OPTICAL MATERIALS 6.3(2018). |
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