Lipid metabolism and oxidative stress in HPV-related cancers

doi:10.1016/j.freeradbiomed.2021.06.009

KMS > iHuman研究所 > 特聘教授组 > Kurt Wuthrich组

	Lipid metabolism and oxidative stress in HPV-related cancers
	Cruz-Gregorio, Alfredo 1; Aranda-Rivera, Ana Karina 2,3; Ortega-Lozano, Ariadna Jazmin 2; Pedraza-Chaverri, Jose 2; Mendoza-Hoffmann, Francisco4,5
	2021-08-20
发表期刊	FREE RADICAL BIOLOGY AND MEDICINE (IF:7.1[JCR-2023],7.9[5-Year])
ISSN	0891-5849
EISSN	1873-4596
卷号	172 页码:226-236
DOI	10.1016/j.freeradbiomed.2021.06.009
摘要	High-risk human papillomavirus (HR-HPVs) are associated with the development of cervical, anus, vagina, vulva, penis, and oropharynx cancer. HR-HPVs target and modify the function of different cell biomolecules such as glucose, amino acids, lipids, among others. The latter induce cell proliferation, cell death evasion, and genomic instability resulting in cell transformation. Moreover, lipids are essential biomolecules in HR-HPVs infection and cell vesicular trafficking. They are also critical in producing cellular energy, the epithelial-mesenchymal transition (EMT) process, and therapy resistance of HPV-related cancers. HPV proteins induce oxidative stress (OS), which in turn promotes lipid peroxidation and cell damage, resulting in cell death such as apoptosis, autophagy, and ferroptosis. HR-HPV-related cancer cells cope with OS and lipid peroxidation, preventing cell death; however, these cells are sensitized by OS, which could be used as a target for redox therapies to induce their elimination. This review focuses on the role of lipids in HR-HPV infection and HPV-related cancer development, maintenance, resistance to therapy, and the possible treatments associated with lipids. Furthermore, we emphasize the significant role of OS in lipid peroxidation to induce cell death through apoptosis, autophagy, and ferroptosis to eliminate HPV-related cancers.
关键词	Lipid metabolism Cellular trafficking beta-oxidation Lipogenesis Epithelial-mesenchymal transition (EMT) Reactive oxygen species (ROS) Ferroptosis autophagy Apoptosis
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000685094600002
出版者	ELSEVIER SCIENCE INC
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127979
专题	iHuman研究所_特聘教授组_Kurt Wuthrich组
通讯作者	Cruz-Gregorio, Alfredo
作者单位	1.Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F225, Ciudad De Mexico 04510, Mexico; 2.Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F315, Ciudad De Mexico 04510, Mexico; 3.Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Ciudad Univ, Ciudad De Mexico 04510, Mexico; 4.ShanghaiTech Univ, IHuman Inst, Shanghai, Peoples R China; 5.Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Lab F206, Ciudad De Mexico 04510, Mexico
推荐引用方式 GB/T 7714	Cruz-Gregorio, Alfredo,Aranda-Rivera, Ana Karina,Ortega-Lozano, Ariadna Jazmin,et al. Lipid metabolism and oxidative stress in HPV-related cancers[J]. FREE RADICAL BIOLOGY AND MEDICINE,2021,172:226-236.
APA	Cruz-Gregorio, Alfredo,Aranda-Rivera, Ana Karina,Ortega-Lozano, Ariadna Jazmin,Pedraza-Chaverri, Jose,&Mendoza-Hoffmann, Francisco.(2021).Lipid metabolism and oxidative stress in HPV-related cancers.FREE RADICAL BIOLOGY AND MEDICINE,172,226-236.
MLA	Cruz-Gregorio, Alfredo,et al."Lipid metabolism and oxidative stress in HPV-related cancers".FREE RADICAL BIOLOGY AND MEDICINE 172(2021):226-236.