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ShanghaiTech University Knowledge Management System
| Generation of three iPSC cell lines (SIAISi006-A, SIAISi007-A and SIAISi008-A) from a 66-year-old Alzheimer's disease (AD) patient and her two unaffected children from Chinese Han population | |
| 2021-03 | |
| 发表期刊 | STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year]) |
| ISSN | 1873-5061 |
| EISSN | 1876-7753 |
| 卷号 | 51 |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.scr.2021.102172 |
| 摘要 | A 66-year-old Chinese Han Alzheimer's Disease (AD) female patient and her two unaffected children donated their Peripheral blood mononuclear cells (PBMC). Non-integrating episomal vector system were used to reprogram their PBMCs with human OKSM (OCT3/4, KLF4, SOX2, and c-MYC) transcription factors. Immunocytochemistry for pluripotency makers confirmed the pluripotency of transgene-free iPSCs. Pluripotency was confirmed by the ability of iPSCs to spontaneously differentiate three germ layers in vitro as well. The iPSC line displayed a normal karyotype. This model provides insight into further pathological studies to research identify early biomarkers, study disease pedigrees, and also for drug testing purposes. |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Cell Biology ; Biotechnology & Applied Microbiology |
| WOS类目 | Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology |
| WOS记录号 | WOS:000629039100022 |
| 出版者 | ELSEVIER |
| 原始文献类型 | Article |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126171 |
| 专题 | 生命科学与技术学院_硕士生 生命科学与技术学院_博士生 免疫化学研究所_PI研究组_赵简组 |
| 共同第一作者 | Zhao, Jian |
| 通讯作者 | Deng, Yulei; Wang, Ying |
| 作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 3.Jiaotong Univ, Shanghai Ruijin Hosp, Neurol Dept, Sch Med, Shanghai, Peoples R China |
| 第一作者单位 | 免疫化学研究所; 生命科学与技术学院 |
| 通讯作者单位 | 免疫化学研究所 |
| 第一作者的第一单位 | 免疫化学研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Wenxin,Dai, Qiuting,Hua, Yishi,et al. Generation of three iPSC cell lines (SIAISi006-A, SIAISi007-A and SIAISi008-A) from a 66-year-old Alzheimer's disease (AD) patient and her two unaffected children from Chinese Han population[J]. STEM CELL RESEARCH,2021,51. |
| APA | Zhang, Wenxin.,Dai, Qiuting.,Hua, Yishi.,Di, Weihao.,Guo, Jinghui.,...&Wang, Ying.(2021).Generation of three iPSC cell lines (SIAISi006-A, SIAISi007-A and SIAISi008-A) from a 66-year-old Alzheimer's disease (AD) patient and her two unaffected children from Chinese Han population.STEM CELL RESEARCH,51. |
| MLA | Zhang, Wenxin,et al."Generation of three iPSC cell lines (SIAISi006-A, SIAISi007-A and SIAISi008-A) from a 66-year-old Alzheimer's disease (AD) patient and her two unaffected children from Chinese Han population".STEM CELL RESEARCH 51(2021). |
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