Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo

doi:10.1093/gbe/evaa207

	Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo
	Hoh, Boon-Peng 1,2; Zhang, Xiaoxi1,3 ; Deng, Lian 1; Yuan, Kai 1; Yew, Chee-Wei 4; Saw, Woei-Yuh 5; Hoque, Mohammad Zahirul 6; Aghakhanian, Farhang 7; Phipps, Maude E.7; Teo, Yik-Ying 5,8,9,10,11; Subbiah, Vijay Kumar 4; Xu, Shuhua1,3,12,13,14
	2020-12
发表期刊	GENOME BIOLOGY AND EVOLUTION (IF:3.2[JCR-2023],3.2[5-Year])
ISSN	1759-6653
卷号	12 期号:12 页码:2245-2257
DOI	10.1093/gbe/evaa207
摘要	North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of similar to 2.2 million genome-wide single nucleotide polymorphisms. As a result, an similar to 13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1-BTNL2-HL4-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB populations and is estimated to have arisen similar to 5.5 thousand years (similar to 220 generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment.
关键词	natural selection North Borneo malaria BTNL2 TSBP1 HLA-DRA
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Evolutionary Biology ; Genetics & Heredity
WOS类目	Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:000606568300004
出版者	OXFORD UNIV PRESS
WOS关键词	INDIGENOUS POPULATIONS ; PLASMODIUM-FALCIPARUM ; NATURAL-SELECTION ; GENOME ; HISTORY ; MALARIA ; ADAPTATION ; ASSOCIATION ; GENETICS ; ORIGIN
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125966
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_徐书华组生命科学与技术学院_博士生
通讯作者	Teo, Yik-Ying; Subbiah, Vijay Kumar; Xu, Shuhua
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China; 2.UCSI Univ, Fac Med & Hlth Sci, Jalan Menara Gading, Kuala Lumpur, Malaysia; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Univ Malaysia Sabah, Biotechnol Res Inst, Jalan UMS, Kota Kinabalu, Sabah, Malaysia; 5.Natl Univ Singapore, Fac Sci, Dept Stat & Appl Probabil, Singapore, Singapore; 6.Univ Malaysia Sabah, Fac Med & Hlth Sci, Jalan UMS, Kota Kinabalu, Sabah, Malaysia; 7.Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Subang Jaya, Selangor, Malaysia; 8.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore; 9.Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore; 10.Natl Univ Singapore, Life Sci Inst, Singapore, Singapore; 11.Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore; 12.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China; 13.Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China; 14.Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hoh, Boon-Peng,Zhang, Xiaoxi,Deng, Lian,et al. Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo[J]. GENOME BIOLOGY AND EVOLUTION,2020,12(12):2245-2257.
APA	Hoh, Boon-Peng.,Zhang, Xiaoxi.,Deng, Lian.,Yuan, Kai.,Yew, Chee-Wei.,...&Xu, Shuhua.(2020).Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.GENOME BIOLOGY AND EVOLUTION,12(12),2245-2257.
MLA	Hoh, Boon-Peng,et al."Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo".GENOME BIOLOGY AND EVOLUTION 12.12(2020):2245-2257.