Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis

doi:10.1016/j.jnutbio.2020.108493

	Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis
	Bai, Meijuan 1; Wang, Yan 2; Han, Ruomei1,3 ; Xu, Lijiao1,3 ; Huang, Meiqin 1; Zhao, Jingyu 1; Lin, Yijun 1; Song, Shuo 1,3; Chen, Yan1,3
	2021-01
发表期刊	JOURNAL OF NUTRITIONAL BIOCHEMISTRY (IF:4.8[JCR-2023],5.4[5-Year])
ISSN	0955-2863
卷号	87
发表状态	已发表
DOI	10.1016/j.jnutbio.2020.108493
摘要	Dietary interventions such as fasting have been proved to be effective in the prevention of metabolic and autoimmune diseases as well as aging-related conditions. The complicated interaction between nutrition and immunity has drawn wide attention in recent years. In this study, we investigated the therapeutic effect of intermittent caloric restriction on autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, in mice. EAE was induced by immunization of C57BL/6 mice with myelin oligodendrocyte glycoprotein 35-55 peptide. After the EAE symptoms became obvious at the 4th week post-immunization, the mice were administered with a modified fasting-mimicking diet (FMD) at 1/3 cal of control for 3 days, followed by ad libitum with normal chow for 4 days. A total of two cycles of FMD was applied. Compared with the mice without receiving caloric restriction, the mice using FMD had significant decreases in EAE severity, immune cell infiltration in spinal cord and CNS demyelination. FMD administration also reversed EAE-mediated CNS accumulation of total CD4+ T cells and in particular, IFN-gamma-producing CD4+ T cells. Moreover, FMD application elevated the cell proliferation rate in CNS and enhanced expression of brain-derived neurotrophic factor (BDNF) and remyelination markers. In conclusion, our results indicate that intermittent caloric restriction using the modified FMD was effective in the treatment of EAE through ameliorating inflammatory response and promoting recovery of the damaged tissue. (C) 2020 Elsevier Inc. All rights reserved.
关键词	Nutritional intervention Multiple sclerosis Autoimmune disease Caloric restriction Inflammatory response Myelination
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31,630,036] ; Ministry of Science and Technology of China[2016YFA0500103] ; Chinese Academy of Sciences[XDA12010102][QYZDJ-SSWSMC008][ZDRW-ZS-2016-8]
WOS研究方向	Biochemistry & Molecular Biology ; Nutrition & Dietetics
WOS类目	Biochemistry & Molecular Biology ; Nutrition & Dietetics
WOS记录号	WOS:000594724900013
出版者	ELSEVIER SCIENCE INC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124951
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_陈雁组生命科学与技术学院_博士生
通讯作者	Chen, Yan
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tumor & Microenvironm, Shanghai 200031, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Bai, Meijuan,Wang, Yan,Han, Ruomei,et al. Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2021,87.
APA	Bai, Meijuan.,Wang, Yan.,Han, Ruomei.,Xu, Lijiao.,Huang, Meiqin.,...&Chen, Yan.(2021).Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,87.
MLA	Bai, Meijuan,et al."Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 87(2021).