De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

doi:10.1126/sciadv.abc4275

	De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function
	Wu, Ruohan 1; Chen, Xuyong 1; Kang, Siwen 1; Wang, Tingting 1; Gnanaprakasam, Jn Rashida 1; Yao, Yufeng2 ; Liu, Lingling 1; Fan, Gaofeng2 ; Burns, Mark R.3; Wang, Ruoning 1
	2020-12
发表期刊	SCIENCE ADVANCES (IF:11.7[JCR-2023],13.7[5-Year])
ISSN	2375-2548
卷号	6 期号:51
发表状态	已发表
DOI	10.1126/sciadv.abc4275
摘要	Robust and effective T cell-mediated immune responses require proper allocation of metabolic resources through metabolic pathways to sustain the energetically costly immune response. As an essential class of polycationic metabolites ubiquitously present in all living organisms, the polyamine pool is tightly regulated by biosynthesis and salvage pathway. We demonstrated that arginine is a major carbon donor and glutamine is a minor carbon donor for polyamine biosynthesis in T cells. Accordingly, the dependence of T cells can be partially relieved by replenishing the polyamine pool. In response to the blockage of biosynthesis, T cells can rapidly restore the polyamine pool through a compensatory increase in extracellular polyamine uptake, indicating a layer of metabolic plasticity. Simultaneously blocking synthesis and uptake depletes the intracellular polyamine pool, inhibits T cell proliferation, and suppresses T cell inflammation, indicating the potential therapeutic value of targeting the polyamine pool for managing inflammatory and autoimmune diseases.
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收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Institutes of Health (Cancer Moonshot program)[1R21CA227926-01A1][1UO1CA232488-01] ; National Institutes of Health[1R01AI114581] ; V-Foundation[V2014-001] ; American Cancer Society[128436-RSG-15-180-01-LIB]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000599905500013
出版者	AMER ASSOC ADVANCEMENT SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124918
专题	生命科学与技术学院_PI研究组_范高峰组生命科学与技术学院_博士生
通讯作者	Wang, Ruoning
作者单位	1.Ohio State Univ, Nationwide Childrens Hosp, Abigail Wexner Res Inst, Hematol Oncol & BMT,Ctr Childhood Canc & Blood Di, Columbus, OH 43205 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Aminex Therapeut Inc, Epsom, NH 03234 USA
推荐引用方式 GB/T 7714	Wu, Ruohan,Chen, Xuyong,Kang, Siwen,et al. De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function[J]. SCIENCE ADVANCES,2020,6(51).
APA	Wu, Ruohan.,Chen, Xuyong.,Kang, Siwen.,Wang, Tingting.,Gnanaprakasam, Jn Rashida.,...&Wang, Ruoning.(2020).De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.SCIENCE ADVANCES,6(51).
MLA	Wu, Ruohan,et al."De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function".SCIENCE ADVANCES 6.51(2020).