Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis

doi:10.1021/acs.orglett.0c02871

	Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis
	Wu, Jing 1; Zhao, Si-Meng2 ; Shi, Bao-Bao 1; Bao, Mei-Fen 1; Schinnerl, Johann 3; Cai, Xiang-Hai 1
	2020-10-02
发表期刊	ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN	1523-7060
卷号	22 期号:19 页码:7676-7680
DOI	10.1021/acs.orglett.0c02871
摘要	Meloyunnanines A-C, three alkaloids with an unprecedented skeleton, were isolated from fruits of Melodinus yunnanensis. The structures featuring a caged-6/6/5/6/5/5 ring system were elucidated by the analysis of comprehensive spectroscopic and X-ray data. Biosynthetically, meloyunnanines A-C were assigned to monoterpenoid quinoline alkaloids (MQAs), derived from monoterpenoid indole alkaloids through oxidation and rearrangement. These compounds together with three known Melodinus MQAs were evaluated for their neurotrophic activity and scandine N-4-oxide exhibited significant effect.
收录类别	SCI ; SCIE ; IC
语种	英语
资助项目	Applied Basic Research Key Project of Yunnan[2016FA030] ; National Natural Science Foundation of China[31872677]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000577160700053
出版者	AMER CHEMICAL SOC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123502
专题	iHuman研究所_PI研究组_钟桂生组
通讯作者	Cai, Xiang-Hai
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; 2.ShanghaiTech Univ, iHuman Inst, Shanghai 200031, Peoples R China; 3.Univ Vienna, Dept Bot & Biodivers Res, A-1030 Vienna, Austria
推荐引用方式 GB/T 7714	Wu, Jing,Zhao, Si-Meng,Shi, Bao-Bao,et al. Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis[J]. ORGANIC LETTERS,2020,22(19):7676-7680.
APA	Wu, Jing,Zhao, Si-Meng,Shi, Bao-Bao,Bao, Mei-Fen,Schinnerl, Johann,&Cai, Xiang-Hai.(2020).Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis.ORGANIC LETTERS,22(19),7676-7680.
MLA	Wu, Jing,et al."Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis".ORGANIC LETTERS 22.19(2020):7676-7680.